Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study

Geel, Tineke van; Geusens, Piet; Winkens, Björn; Sels, J. P. J. E.; Dinant, Geert‐Jan

doi:10.1530/eje-08-0702

Cited by 119 publications

(97 citation statements)

References 31 publications

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“…In addition, there is some evidence suggesting the presence of estrogen receptors in human muscle (11). However, other authors did not find any relationship between estradiol and muscle mass (12,13), so the role of estrogens in postmenopausal muscle mass loss continues being controversial. Moreover, the role of gonadotropins in this process is unknown.…”

Section: Introductionmentioning

confidence: 99%

Gonadotropins Are Related to Lean Mass in Healthy Postmenopausal Women

et al. 2012

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Background. It has been suggested that the changes in hormone levels that occur with menopause and aging are related to loss of muscle mass. However, the role of gonadotropins in this process is unknown. Objectives. To analyze the relationship between follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and lean mass in a cohort of healthy women. Methods. This is a cross-sectional study including 91 postmenopausal women (48-65 years old). Serum FSH, LH, and estradiol (E2) were measured. Lean mass was estimated by bioelectrical impedance analysis and expressed as appendicular skeletal muscle mass (AMM) index. Results. AMM index was negatively correlated with FSH levels (r = -0.33, p = 0.001) and LH (r = -0.293, p = 0.005), while there was no association with E2. When muscle mass expressed as AMM index was stratified into tertiles, there were significant differences between the lowest and the highest tertile for both FSH (82.4 ± 30, vs. 67.9 ± 25.8 mIU/mL, p = 0.04) and LH (40.9 ± 15.2 vs. 36.1 ± 12.3 mIU/mL, p = 0.03). In logistic regression analysis adjusted for age and E2 levels, high concentrations of FSH (OR = 1.03, 95% CI = 1.01-1.05, p = 0.008) and LH (OR = 1.06, 95% CI = 1.01-1.1, p = 0.01) were risk factors for having lower lean mass expressed as AMM index. Conclusions. Menopausal women with high levels of gonadotropins have lower levels of lean mass than those with lower gonadotropins levels.

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Section: Introductionmentioning

confidence: 99%

Gonadotropins Are Related to Lean Mass in Healthy Postmenopausal Women

et al. 2012

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“…According to Van Geel et al, there is a positive correlation between lean body mass and estrogen levels [55]. Additionally, estrogen may have a direct effect on muscle mass, as the cell membranes of skeletal muscle contain beta estrogen receptors [56].…”

Section: Treatment Of Muscle Mass Lossmentioning

confidence: 99%

Muscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment

Colón¹,

Molina-Vicenty

Frontera-Rodríguez

et al. 2018

J. Biomed

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Aging is the result of different functional changes leading to a substantial reduction of all human capabilities. A variety of anatomical and physiological changes occur with advancing age. These changes are more evident in the elderly population. There are various methods to measure muscle and bone mass loss, but the dual X-ray absorptiometry (DXA) is considered one of the most efficient. The elderly population (65 years and older) has been increasing throughout the years. Loss of muscle mass (sarcopenia) and loss bone mass (osteopenia or osteoporosis) with advancing age, when untreated, represent a major public health problem for the elderly population and may result in loss of independence in later life. Untreated age-related sarcopenia and osteopenia/osteoporosis increase the risk for falls and fractures, making older individuals more susceptible to the development of mobility limitations or severe disabilities that ultimately affect their capacity for independence. In this review, we will discuss the muscle and bone mass loss in the elderly population and advances in diagnosis and treatment.

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“…Per scopi epidemiologici, i livelli circolanti di estradiolo nelle donne in età menopausale sono associati al rischio di contrarre varie malattie croniche, comprendenti il cancro [21,22], malattie cardiovascolari [23,24] e osteoporosi [25]. L'importanza di una misura affidabile nelle valutazioni epidemiologiche risiede nel fatto che errori casuali nella misurazione delle ma endocrino e in particolare dall'alterazione delle relazioni nell'asse ipotalamo-ipofisi-gonadi [27].…”

Section: Aspetti Cliniciunclassified

Il ruolo del testosterone e dell’estradiolo nell’età avanzata

Tozzoli

Fortunato

2011

Riv Ital Med Lab

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prostata e del fegato. Nel deficit androgenico dell'adulto, vi è accordo nel considerare i livelli di testosterone totale di 230 e 350 ng/dL come soglie decisionali per un approccio clinico differenziato: terapia sostitutiva al di sotto del primo valore, approfondimento diagnostico con il dosaggio del testosterone libero per livelli compresi tra i due valori, esclusione diagnostica di ipogonadismo al di sopra del secondo valore. I livelli di testosterone totale utili per l'inquadramento diagnostico del maschio anziano (superiori a 230 ng/dL) possono essere misurati con prestazioni analitiche accettabili dai comuni metodi diretti immunometrici disponibili nei laboratori clinici su analizzatori automatici.La letteratura internazionale è unanime nella proposta di scoraggiare l'impiego di metodi diretti o con l'analogo marcato per la determinazione del testosterone libero e di raccomandare l'uso di metodi basati sulla dialisi all'equilibrio e sulla precipitazione con ammonio solfato per una corretta valutazione del livello androgenico oppure di ricorrerre alla stima indiretta del testosterone biodisponibile, partendo dalla misura della concentrazione del testosterone, dell'SHBG (Sex Hormone Binding Globulin) e dell'albumina.Una misura accurata dell'estradiolo circolante (E 2 ) a concentrazioni molto basse dell'ormone (inferiori a 30-50 pg/mL) ha un fondamentale ruolo diagnostico e prognostico nella ginecomastia e in varie neoplasie estrogeno-dipendenti nel maschio e nella menopausa e nel cancro della mammella nella femmina. Tuttavia, in tutte queste condizioni, la determinazione dell'estradiolo non Riassunto Nell'anziano variazioni clinicamente significative della concentrazione degli ormoni steroidei testosterone ed estradiolo sono presenti nel maschio, nel deficit androgenico dell'adulto e nella ginecomastia, e nella femmina, nella sindrome climaterica: in queste condizioni il dosaggio dei due steroidi ha un importante ruolo nella diagnosi o nel monitoraggio di terapie specifiche sostitutive.La misura delle concentrazioni dell'estradiolo ha, inoltre, significato in studi epidemiologici per valutare il ruolo etiologico dell'estrogeno in condizioni cliniche

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Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study

Cited by 119 publications

References 31 publications

Gonadotropins Are Related to Lean Mass in Healthy Postmenopausal Women

Gonadotropins Are Related to Lean Mass in Healthy Postmenopausal Women

Muscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment

Il ruolo del testosterone e dell’estradiolo nell’età avanzata

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