Measures of Location and Dispersion of Sleep State Distributions Within the Circular Frame of a 12:12 Light: Dark Schedule in the Rat

Vivaldi, E; Wyneken, Úrsula; Roncagliolo, Manuel; Ocampo, Adrian; Zapata, Ana M.

doi:10.1093/sleep/17.3.208

Cited by 10 publications

(14 citation statements)

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“…At the core of the short‐term REM sleep homeostasis hypothesis is the concept that during a REM sleep episode REM sleep pressure is dissipated so that the longer the episode, the less REM sleep pressure remains and the longer the interval to the next REM sleep episode. Observations in the cat (Ursin 1970), rat (Benington and Heller 1994a; Vivaldi et al . 1994b) and human (Barbato and Wehr 1998) are consistent with this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

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Short‐term homeostasis of REM sleep assessed in an intermittent REM sleep deprivation protocol in the rat

Ocampo-Garcés

Vivaldi

2002

Journal of Sleep Research

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An intermittent rapid eye movement (REM) sleep deprivation protocol was applied to determine whether an increase in REM sleep propensity occurs throughout an interval without REM sleep comparable with the spontaneous sleep cycle of the rat. Seven chronically implanted rats under a 12 : 12 light–dark schedule were subjected to an intermittent REM sleep deprivation protocol that started at hour 6 after lights‐on and lasted for 3 h. It consisted of six instances of a 10‐min REM sleep permission window alternating with a 20‐min REM sleep deprivation window. REM sleep increased throughout the protocol, so that total REM sleep in the two REM sleep permission windows of the third hour became comparable with that expected in the corresponding baseline hour. Attempted REM sleep transitions were already increased in the second deprivation window. Attempted transitions to REM sleep were more frequent in the second than in the first half of any 20‐min deprivation window. From one deprivation window to the next, transitions to REM sleep changed in correspondence to the amount of REM sleep in the permission window in‐between. Our results suggest that: (i) REM sleep pressure increases throughout a time segment similar in duration to a spontaneous interval without REM sleep; (ii) it diminishes during REM sleep occurrence; and (iii) that drop is proportional to the intervening amount of REM sleep. These results are consistent with a homeostatic REM sleep regulatory mechanism that operates in the time scale of spontaneous sleep cycle.

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Section: Discussionmentioning

confidence: 99%

“…(Roncagliolo and Vivaldi 1991; Vivaldi et al . 1994a,b). The algorithm favored the scoring of REM sleep over NREM sleep, so that an epoch could be assigned to REM sleep even if less than half of it actually belonged to that state.…”

Section: Methodsmentioning

confidence: 99%

Short‐term homeostasis of REM sleep assessed in an intermittent REM sleep deprivation protocol in the rat

Ocampo-Garcés

Vivaldi

2002

Journal of Sleep Research

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“…An automated computer-based acquisition system designed for long term sleep-wake recording was adapted to record rest activity rhythm (Vivaldi et al, 1994). The system recorded and stored the activity counts detected by a piezoelectric device placed at the base of the animal's cage originally in 15-second intervals.…”

Section: Data Acquisitionmentioning

confidence: 99%

Wheel-running and rest activity pattern interaction in two octodontids (Octodon degus, Octodon bridgesi)

et al. 2005

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Wheel-running and other non-photic stimuli influence the rest-activity pattern of diurnal and nocturnal mammals. A day to night inversion of phase preference of activity was described among Octodon degus, when exposed to ad-libitum wheel running. We have studied the rest-activity pattern response in presence of ad libitum wheel-running in wild-captured male individuals from two species of genus Octodon: O. degus (n=9, crepuscular-diurnal) and O. bridgesi (n=3, nocturnal). After two months of habituation to laboratory conditions, recordings were performed in isolation chambers under a 12:12 light-dark schedule with or without access to a running wheel. Actograms were constructed from data obtained by an automated acquisition system. O. bridgesi were also recorded under constant darkness, with or without access to wheelrunning. Entrained to the light-dark schedule, a crepuscular pattern of activity was evident for O. degus, whereas O. bridgesi displayed a robust nocturnal chronotype. The activity of O. degus observed during the dark phase was enhanced when wheel-running was allowed. No significant change in phase preference was observed for O. bridgesi when wheel-running was allowed. A lengthening of endogenous period was observed in O. bridgesi after wheel-running exposure under constant darkness. Nocturnal and diurnal octodontids exhibit different masking responses to wheel-running.

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“…, 2007). When entrained to a 12 : 12 light‐dark (LD) cycle, wakefulness is concentrated during the active (lights‐off) phase, while non‐rapid eye movement (NREM) sleep and REM sleep maximal incidences are located in the first and second half of the rest (lights‐on) phase, respectively (Vivaldi et al. , 1994).…”

Section: Introductionmentioning

confidence: 99%

“…, 2002). REM sleep generators receive robust circadian modulation determining a markedly sinusoidal temporal profile of state expression (Vivaldi et al. , 1994, 2005; Wurts and Edgar, 2000).…”

Section: Introductionmentioning

confidence: 99%

Orexin‐B‐saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat

Ocampo-Garcés

Ibáñez

Perdomo

et al. 2011

Journal of Sleep Research

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SUMMAR Y The 24-h distribution of rapid eye movement (REM) sleep is known to be deeply reshaped among albino rats with neurotoxic lesions in the lateral hypothalamus (LH) or among rodent models of human narcolepsy-cataplexy, with selective damage of orexinergic neurones. We explored the hypothesis that this phenomenon is explained by an enhancement of REM sleep photic masking, as a consequence of damage in the LH. Orexin-B-saporin neurotoxic lesions were induced in the LH of male Sprague-Dawley rats. LH-lesioned and control rats were sleep-recorded successively under 12 : 12 light ⁄ dark (LD) and skeleton photoperiod. Compared to controls, lesioned rats exhibited 50% less and 82% more REM sleep during rest and active phases, respectively, under the 12 : 12 LD schedule. After transference to a skeleton photoperiod, lesioned rats exhibited an 88% increase in REM sleep during the rest phase, recovering the characteristic rest phase preference of REM sleep observed among control rats. The increase in rest phase REM sleep during the skeleton photoperiod was correlated positively with the magnitude of the LH lesion. Our results suggest that changes in the temporal organization of sleep-wake states observed among rats with neurotoxic lesions in the lateral hypothalamus and rodent models of narcolepsy-cataplexy may be explained by the enhancement of photic masking.k e y w o r d s lateral hypothalamus, masking, orexin, orexin-B-saporin, REM sleep, skeleton photoperiod

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Measures of Location and Dispersion of Sleep State Distributions Within the Circular Frame of a 12:12 Light: Dark Schedule in the Rat

Cited by 10 publications

References 0 publications

Short‐term homeostasis of REM sleep assessed in an intermittent REM sleep deprivation protocol in the rat

Short‐term homeostasis of REM sleep assessed in an intermittent REM sleep deprivation protocol in the rat

Wheel-running and rest activity pattern interaction in two octodontids (Octodon degus, Octodon bridgesi)

Orexin‐B‐saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat

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