Measures of Sleep–Wake Patterns and Risk of Mild Cognitive Impairment or Dementia in Older Women

Diem, Susan J.; Blackwell, Terri; Stone, Katie L.; Yaffe, Kristine; Tranah, Greg; Cauley, Jane A.; Ancoli‐Israel, Sonia; Redline, Susan; Spira, Adam P.; Hillier, Teresa A.; Ensrud, Kristine E.

doi:10.1016/j.jagp.2015.12.002

Cited by 118 publications

(119 citation statements)

References 44 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Both behavioural therapies and prescription medications are considered effective means to treat insomnia. Reports have suggested that addressing the conditions of depression and cognitive impairment in the elderly population may help improve not only their quality of life but also reduce insomnia …”

Section: Other Medical Conditions Contributing To Sleep Problems Of Omentioning

confidence: 99%

Sleep disorders in the elderly: a growing challenge

2018

View full text Add to dashboard Cite

In contrast to newborns, who spend 16-20 h in sleep each day, adults need only about sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition to changes in sleep duration, sleep patterns change as age progresses. Like the physical changes that occur during old age, an alteration in sleep pattern is also a part of the normal ageing process. As people age, they tend to have a harder time falling asleep and more trouble staying asleep. Older people spend more time in the lighter stages of sleep than in deep sleep. As the circadian mechanism in older people becomes less efficient, their sleep schedule is shifted forward. Even when they manage to obtain 7 or 8 h sleep, they wake up early, as they have gone to sleep quite early. The prevalence of sleep disorders is higher among older adults. Loud snoring, which is more common in the elderly, can be a symptom of obstructive sleep apnoea, which puts a person at risk for cardiovascular diseases, headaches, memory loss, and depression. Restless legs syndrome and periodic limb movement disorder that disrupt sleep are more prevalent in older persons. Other common medical problems of old age such as hypertension diabetes mellitus, renal failure, respiratory diseases such as asthma, immune disorders, gastroesophageal reflux disease, physical disability, dementia, pain, depression, and anxiety are all associated with sleep disturbances.

show abstract

Section: Other Medical Conditions Contributing To Sleep Problems Of Omentioning

confidence: 99%

Sleep disorders in the elderly: a growing challenge

2018

View full text Add to dashboard Cite

show abstract

“…Apart from cross‐sectional results, several longitudinal studies have addressed the role of sleep in cognitive decline. According to these studies, future risk of cognitive deterioration or conversion from MCI to dementia was predictable by different measures of sleep disturbances as assessed by self‐rating scales, actigraphy, and polysomnography …”

Section: Introductionmentioning

confidence: 99%

Actigraphic, but not subjective, sleep measures are associated with cognitive impairment in memory clinic patients

et al. 2019

View full text Add to dashboard Cite

Aim Sleep disturbances are prevalent in various dementia subtypes but rarely investigated in early clinical stages. Although memory clinics have become an established institution for the early diagnosis of dementia, sleep assessment is not part of their routine diagnostics. This study aimed to examine whether subjective and objective sleep variables are related to cognitive impairment in patients referred to a memory clinic. Methods On two consecutive days, patients underwent routine diagnostic procedures, including a neuropsychological examination (consortium to establish a registry for alzheimer's disease), and had their sleep quality evaluated by the Pittsburgh Sleep Quality Index and overnight hand‐wrist actigraphy. Results Data of 31 patients (age, M ± SEM: 74.1 ± 1.5; 18 women, 13 men; Clinical Dementia Rating: 0–1) were analysed. One had been diagnosed with subjective cognitive impairment, 13 with mild cognitive impairment with or without depression, and 17 with dementia syndrome due to Alzheimer's and/or cerebrovascular disease. Compared to patients with subjective or mild cognitive impairment, dementia patients showed a significantly increased nocturnal acceleration magnitude; other differences in subjective and objective sleep measures were not significant. Comparing patients with subjectively poor (Pittsburgh Sleep Quality Index > 5: n = 9) and good sleep (Pittsburgh Sleep Quality Index ≤ 5: n = 22) yielded no differences in any neuropsychological and clinical variables. In contrast, patients with low actigraphically recorded sleep efficiency (<85%: n = 11) exhibited a significantly more impaired cognitive performance than those in the high sleep efficiency group (≥85%: n = 20). Correlation analyses demonstrated that actigraphically assessed disturbed sleep continuity accompanied by increased night‐time motor activity was substantially associated with cognitive impairment. Conclusion This study highlights that objectively assessed, but not self‐reported, parameters of disturbed sleep are closely related to cognitive dysfunction in the early stages of dementia of different aetiologies. Possible diagnostic and treatment implications are discussed.

show abstract

“…5 Recent prospective cohort studies, using both objective and subjective measures of sleep quality, offered strong evidence that poor sleep led to cognitive decline in older adults. 6,7 It is also possible that frequent nocturnal awakenings increase caregiver burden and stress, which prompts the institutionalization of older adults receiving care at home. 8 However, one could argue that poor sleep in care recipients may not necessarily be linked to disturbed sleep in caregivers.…”

Section: Poor Sleep and The Risk Of Long-term Care Placementmentioning

confidence: 99%

Sleep and Long-Term Care

Richards

2018

Sleep Medicine Clinics

View full text Add to dashboard Cite

Measures of Sleep–Wake Patterns and Risk of Mild Cognitive Impairment or Dementia in Older Women

Cited by 118 publications

References 44 publications

Sleep disorders in the elderly: a growing challenge

Sleep disorders in the elderly: a growing challenge

Actigraphic, but not subjective, sleep measures are associated with cognitive impairment in memory clinic patients

Sleep and Long-Term Care

Contact Info

Product

Resources

About