Measuring cavitation and its cleaning effect

Verhaagen, B.; Rivas, David Fernández

doi:10.1016/j.ultsonch.2015.03.009

Cited by 153 publications

(83 citation statements)

References 83 publications

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“…Biofilms, 16,75 which consist of a complex 3D structure allying bacteria, substances secreted by the latter and exogenous proteins coming from the host environment, are found, for instance, on implants and prostheses, in the mouth in the form of dental plaque 76 and in the root canals, 77 or on medical devices. Simply through their impact on surfaces, bubbles which flow in the vicinity of a biofilm have proven to efficiently remove bacterial contamination.…”

Section: E Biofilmsmentioning

confidence: 99%

In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications

et al. 2016

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Besides their use as contrast agents for ultrasound imaging, microbubbles are increasingly studied for a wide range of therapeutic applications. In particular, their ability to enhance the uptake of drugs through the permeabilization of tissues and cell membranes shows great promise. In order to fully understand the numerous paths by which bubbles can interact with cells and the even larger number of possible biological responses from the cells, thorough and extensive work is necessary. In this review, we consider the range of experimental techniques implemented in in vitro studies with the aim of elucidating these microbubble-cell interactions. First of all, the variety of cell types and cell models available are discussed, emphasizing the need for more and more complex models replicating in vivo conditions together with experimental challenges associated with this increased complexity. Second, the different types of stabilized microbubbles and more recently developed droplets and particles are presented, followed by their acoustic or optical excitation methods. Finally, the techniques exploited to study the microbubble-cell interactions are reviewed. These techniques operate over a wide range of timescales, or even off-line, revealing particular aspects or subsequent effects of these interactions. Therefore, knowledge obtained from several techniques must be combined to elucidate the underlying processes. V C 2016 AIP Publishing LLC.

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Section: E Biofilmsmentioning

confidence: 99%

In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications

et al. 2016

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“…The interaction of optical radiation with biological tissue is multifaceted and, in particular, is accompanied by the occurrence of acoustic noise and the formation of bubbles (Mettin, 2007;Yusupov et al, 2014). Cavitation bubbles can effectively disinfect biological tissues, as has been reported in several studies (Lifshitz et al, 2005;Verhaagen and Rivas, 2016), so they attract special attention.…”

Section: Introductionmentioning

confidence: 99%

Control of Bubble Formation at the Optical Fiber Tip by Analyzing Ultrasound Acoustic Waves

Казаков

Yusupov

Баграташвили

et al. 2016

American Journal of Engineering and Applied Sciences

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The problems of controlling the processes of generation of acoustic waves and microbubbles at the optical fiber tip of moderatepower surgical lasers with wavelengths of 1.9 µm and 0.97 µm using active and passive acoustic methods are considered. It is shown that microbubbles of various sizes can be detected with an ultrasound method, in which the interaction area is recorded simultaneously at two frequencies. By measuring noise with a receiving transducer of an ultrasonic locator, we determine the frequency range of the acoustic signals occurring when large diameter bubbles, including gas-vapor bubbles, collapse. Model experiments are conducted to detect noise and bubbles in water and in a water-saturated 1.5% agarose phantom at various laser powers with an optical fiber tip having a strongly absorbing coating.

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“…3,7,8 The cavitation bubbles collapse, creating powerful acoustic streaming and shock waves causing, in particular, the death of bacteria, and thereby sterilizing the wound. 9,10 Changes in tissue properties may result in nonuniform ablation followed by overheating of particular areas of the tissue and the formation of necrosis. In order to eliminate this negative factor, automatic adjustment of laser power by measuring the temperature of the optical¯ber tip is used.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11] These methods have been developed to a considerable extent for the detection of single bubbles excited by acoustic waves at their resonant frequencies of di®erent modes of oscillation in a water. 12 Use of the above methods is well-known in relation to the detection of bubbles during decompression, or phospholipidcoated micro-bubbles in order to increase ultrasonic image contrast.…”

Section: Introductionmentioning

confidence: 99%

On the possible ultrasonic inspection of micro-bubbles generated by the optical fiber tip

Казаков

Sanin

Kamensky

2016

J. Innov. Opt. Health Sci.

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We demonstrate the possibility of detection and monitoring of bubbles emerging near the tip of an optical¯ber by means of ultrasonic method. The excitation of bubbles at their resonant frequencies is performed using short ultrasonic pulses having a wide frequency range simultaneously with their modulation by means of a long pulse of a monochromatic frequency. This method allows detection of bubbles of various sizes. Used signal processing method, which allows increased bubble detection accuracy, is proposed for research in environments of biological-like medium which show continuous variations in structure and properties when exposed to optical emission. The method has been demonstrated on model objects: in a liquid and in a biological tissue phantom using various methods of bubble generation (hydrolysis and optical emission). We studied bubble formation by the tip of a¯ber of the surgical laser LSP-007/10 \IRE Polus" with a wavelength of 0.97 m coated with a highly absorbing graphite layer.

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Measuring cavitation and its cleaning effect

Cited by 153 publications

References 83 publications

In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications

In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications

Control of Bubble Formation at the Optical Fiber Tip by Analyzing Ultrasound Acoustic Waves

On the possible ultrasonic inspection of micro-bubbles generated by the optical fiber tip

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