Measuring Cortical Activity During
Auditory Processing With Functional
Near-Infrared Spectroscopy

Rijt, Luuk P. H. van de; Wanrooij, Marc M. Van; Snik, A.F.M.; Mylanus, Emmanuel A. M.; Opstal, A. John Van; Roye, Anja

doi:10.17430/1003278

Cited by 12 publications

(10 citation statements)

References 86 publications

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“…Functional Near-Infrared Spectroscopy (fNIRS) allows performing in vivo a continuous and non-invasive monitoring of oxygenation levels of chromophores like hemoglobin ( Van de Rijt et al, 2018 ), thanks to the transparency of biological tissues -including the human brain- to the light in the near-infrared spectrum. Indeed, fNIRS quantifies regional changes in the concentration of oxygenated, deoxygenated, and total hemoglobin (OxyHb, DeoxyHb, and TotHb).…”

Section: Introductionmentioning

confidence: 99%

Looking for “fNIRS Signature” in Autism Spectrum: A Systematic Review Starting From Preschoolers

et al. 2022

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Accumulating evidence suggests that functional Near-Infrared Spectroscopy (fNIRS) can provide an essential bridge between our current understanding of neural circuit organization and cortical activity in the developing brain. Indeed, fNIRS allows studying brain functions through the measurement of neurovascular coupling that links neural activity to subsequent changes in cerebral blood flow and hemoglobin oxygenation levels. While the literature offers a multitude of fNIRS applications to typical development, only recently this tool has been extended to the study of neurodevelopmental disorders (NDDs). The exponential rise of scientific publications on this topic during the last years reflects the interest to identify a “fNIRS signature” as a biomarker of high translational value to support both early clinical diagnosis and treatment outcome. The purpose of this systematic review is to describe the updating clinical applications of fNIRS in NDDs, with a specific focus on preschool population. Starting from this rationale, a systematic search was conducted for relevant studies in different scientific databases (Pubmed, Scopus, and Web of Science) resulting in 13 published articles. In these studies, fNIRS was applied in individuals with Autism Spectrum Disorder (ASD) or infants at high risk of developing ASD. Both functional connectivity in resting-state conditions and task-evoked brain activation using multiple experimental paradigms were used in the selected investigations, suggesting that fNIRS might be considered a promising method for identifying early quantitative biomarkers in the autism field.

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Section: Introductionmentioning

confidence: 99%

Looking for “fNIRS Signature” in Autism Spectrum: A Systematic Review Starting From Preschoolers

et al. 2022

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“…In addition, HL can present difficulty distinguishing high-pitched vs soft sounds rather than true difficulty of hearing, which also leads to underrecognition . Patients’ denial could be another possibility due to the stigma associated with HL, fear of use and/or cost related to hearing aids, and thus result in underdetection by health care professionals and adverse effects on patients’ quality of life . A higher prevalence of subjective and objective HL was seen in cancer survivors who had a previous hearing test than those who have never had a hearing test, implying that cancer survivors may experience more severe HL, which prompted a past hearing test.…”

Section: Discussionmentioning

confidence: 99%

Subjective and Objective Hearing Loss Among US Adult Cancer Survivors

Wang,

Jiang,

Wen

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceCancer survivors are at a higher risk of developing hearing loss (HL) due to older age, chemotherapy, and radiotherapy. However, the prevalence of HL among US cancer survivors remains unknown. Additionally, there is a lack of uniform HL screening guidelines for this enlarging population.ObjectiveTo estimate the prevalence of subjective HL and objective HL by audiometry test among cancer survivors and compare them with the general population as well as to assess the performance of subjective HL questions in detecting true (ie, audiometry-confirmed) HL.Design, Setting, and ParticipantsIn a cross-sectional design, adults between ages 20 and 80 years who had audiometry testing and responded to a hearing questionnaire from the National Health and Nutrition Examination Survey (2011-2012, 2015-2016, and 2017 to March 2020 prepandemic survey cycles) were selected. Data analysis was conducted from August 13, 2022, to July 26, 2023.Main Outcomes and MeasuresThe weighted prevalence of subjective HL (troublesome hearing and tinnitus) and objective HL (speech-frequency HL and high-frequency HL) by audiometry were calculated. Analyses with χ2 testing and multiadjusted logistic regression models were used to compare HL between cancer survivors and the general population. To evaluate the performance of subjective HL questions as a tool to screen for objective HL by audiometry, areas under the curve were estimated using age- and gender-adjusted logistic regression.ResultsAmong the total 9337 participants (weighted n = 90 098 441; 51.2% women), 10.3% were cancer survivors. Compared with the general population, cancer survivors had a higher prevalence of troublesome hearing (adjusted odds ratio [AOR], 1.43; 95% CI, 1.11-1.84), tinnitus (AOR, 1.28; 95% CI, 0.94-1.74), speech-frequency HL (AOR, 1.43; 95% CI, 1.11-1.85), and high-frequency HL (AOR, 1.74; 95% CI, 1.29-2.34). When using the subjective HL tool and questioning regarding whether the participants were having troublesome hearing and/or tinnitus in screening for HL, the age- and gender-adjusted area under the curve was 0.88 in detecting speech-frequency HL and 0.90 in detecting high-frequency HL.Conclusion and RelevanceThe findings of this study suggest that cancer survivors have a significantly higher prevalence of HL than the general population. Two subjective HL questions could potentially accurately identify those who have true HL and provide a simple and efficient screening tool for health care professionals. Cancer survivors and their families should be educated and encouraged to discuss hearing concerns, and health care professionals should facilitate raising awareness and provide early screening and timely referral when HL is identified.

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“…This phenomenon is referred to as the hemodynamic response function (HRF) and is typically characterized by a 2 s delay between the onset of the electrical neural response. Thus, these changes start with a steep rise that reaches a plateau approximately 6-10 s after the stimulus onset (van de Rijt et al, 2018). Under the neurovascular process, it has been proposed that following neural activation, relaxation of the vascular musculature occurs, increasing blood ow to overcompensate for energy expenditure.…”

Section: Introductionmentioning

confidence: 99%

Neurovascular Coupling During Auditory Stimulation: Event-related Potentials and Fnirs Hemodynamic

Muñoz

Muñoz-Caracuel

Angulo-Ruíz

et al. 2023

Preprint

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Intensity Dependent Amplitude Changes (IDAP) have been extensively studied using Event-Related Potentials (ERPs) and have been linked to several psychiatric disorders. This study aimed to explore the application of functional near-infrared spectroscopy (fNIRS) in IDAP paradigms and to relate it to ERPs. Thirty-three and thirty-one subjects participated in two experiments, respectively. The first experiment consisted of the presentation of three-tone intensities (77.9dB, 84.5dB, and 89.5dB) lasting 500 ms, each type randomly presented 54 times, while the second experiment consisted of the presentation of five-tone intensities (70.9dB, 77.9dB, 84.5dB, 89.5dB, and 95.5dB) in blocks composed of eight tones of the same intensity lasting 70 ms each one, in total 20 blocks were presented. EEG was used to measure ERP components: N1, P2, and N1-P2 peak-to-peak amplitude. fNIRS allowed the analysis of the hemodynamic activity in the auditory and prefrontal cortices. The results showed an increase in N1, P2, and N1-P2 peak-to-peak amplitude with auditory intensity. Similarly, oxyhemoglobin and deoxyhemoglobin concentrations showed amplitude increases and decreases, respectively, with auditory intensity in the auditory and prefrontal cortices. Spearman correlation analysis showed a relationship between the left auditory cortex and N1 and the right dorsolateral cortex and P2 amplitude. These results suggest that there is a brain response to auditory intensity changes that can be obtained by EEG and fNIRS, supporting the neurovascular coupling process. Overall, this study contributes to the understanding and application of fNIRS in auditory paradigms and highlights its potential to be used in a complementary manner to ERPs.

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Measuring Cortical Activity During Auditory Processing With Functional Near-Infrared Spectroscopy

Cited by 12 publications

References 86 publications

Looking for “fNIRS Signature” in Autism Spectrum: A Systematic Review Starting From Preschoolers

Looking for “fNIRS Signature” in Autism Spectrum: A Systematic Review Starting From Preschoolers

Subjective and Objective Hearing Loss Among US Adult Cancer Survivors

Neurovascular Coupling During Auditory Stimulation: Event-related Potentials and Fnirs Hemodynamic

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