Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux

Ryzhikov, Mikhail; Eubanks, Anna; Haspel, Jeffrey A.

doi:10.3791/60133

Cited by 1 publication

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“…Circadian rhythms are daily predictable changes in physiology, behavior and environment with a period of time of approximately 24 h (Greco and Sassone-Corsi, 2020;Kim and Lazar, 2020). They exist on every biological scale, from macroscopic aspects such as sleep-wake cycles to microcosmic phenomena such as the rhythmic abundance of biomolecules (Ryzhikov et al, 2019b;Tan X. et al, 2019;Van Dyck and Casaer, 2019). In mammals, the daily changes are mediated by the hypothalamic master clock located in the suprachiasmatic nucleus (SCN) and by clock oscillations in peripheral tissues, which are synchronized by light and feeding time, respectively (Dreyer et al, 2019;Paul et al, 2020).…”

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confidence: 99%

Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease

Wang

Cai

et al. 2020

Front. Cell Dev. Biol.

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Circadian rhythms are physical, behavioral and environmental cycles that respond primarily to light and dark, with a period of time of approximately 24 h. The most essential physiological functions of mammals are manifested in circadian rhythm patterns, including the sleep-wake cycle and nutrient and energy metabolism. Autophagy is a conserved biological process contributing to nutrient and cellular homeostasis. The factors affecting autophagy are numerous, such as diet, drugs, and aging. Recent studies have indicated that autophagy is activated rhythmically in a clock-dependent manner whether the organism is healthy or has certain diseases. In addition, autophagy can affect circadian rhythm by degrading circadian proteins. This review discusses the interaction and mechanisms between autophagy and circadian rhythm. Moreover, we introduce the molecules influencing both autophagy and circadian rhythm. We then discuss the drugs affecting the circadian rhythm of autophagy. Finally, we present the role of rhythmic autophagy in nutrient and energy metabolism and its significance in physiology and metabolic disease.

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