This paper is the first of a series of papers in which we will apply the methods we have developed for high-precision astrometry (and photometry) with the Hubble Space Telescope (HS T ) to the case of wide-field ground-based images. In particular, we adapt the software originally developed for WFPC2 to ground-based, wide field images from the WFI at the ESO 2.2 m telescope. In this paper, we describe in details the new software, we characterize the WFI geometric distortion, discuss the adopted local transformation approach for proper-motion measurements, and apply the new technique to two-epoch archive data of the two closest Galactic globular clusters: NGC 6121 (M 4) and NGC 6397. The results of this exercise are more than encouraging. We find that we can achieve a precision of ∼7 mas (in each coordinate) in a single exposure for a well-exposed star, which allows a very good cluster-field separation in both M 4, and NGC 6397, with a temporal baseline of only 2.8, and 3.1 years, respectively.