“…Other articles (n = 7) describe rule-based systems paired with traditional machine learning approaches i.e., an ensemble, particularly using NLP systems such as General Architecture for Text Engineering (GATE), Clinical Language Annotation, Modeling, and Processing Toolkit (CLAMP), Extract SDOH from EHRs (EASE), Yale clinical Text Analysis and Knowledge Extraction System (cTAKES), Relative Housing Stability in Electronic Documentation (ReHouSED), and toolkits such as spaCy and medspaCy in conjunction with conditional random fields and support vector machines [110-113]. In contrast, several investigators have leveraged opensource NLP toolkits like spaCy and medspaCy without supervised learners to extractSDoH variables[114][115][116]. Other studies (n = 19) have solely leveraged traditional supervised and unsupervised learning techniques, support vector machines (SVM), logistic regression (LR), NaĂŻve Bayes, Adaboost, Random Forest, XGBoost, Bio-ClinicalBERT, Latent Dirichlet Allocation (LDA), and bidirectional Long Short-Term Memory (BI-LSTM)[16,[117][118][119][120][121] to extract and standardize social and behavioral determinants of health (SBDoH), e.g., alcohol abuse, drug use, sexual orientation, homelessness,substance use, sexual history, HIV status, drug use, housing status, transportation needs, housing insecurity, food insecurity, financial insecurity, employment/income insecurity, insurance insecurity, and poor social support.…”