Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition

Norat, Teresa; Bingham, Sheila; Ferrari, Pietro; Slimani, Nadia; Jenab, Mazda; Mazuir, Mathieu; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Clavel, F; Boutron-Ruault, Marie Christine; Kesse, Emmanuelle; Boeing, Heiner; Bergmann, Manuela M.; Nieters, Alexandra; Linseisen, Jakob; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Tountas, Yannis; Berrino, Franco; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Víneis, Paolo; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.M.; Engeset, Dagrun; Lund, Eiliv; Skeie, Guri; Ardanaz, Eva; González, Carlos; Navarro, Carmen; Quiŕos, J. Ramón; Sánchez, María José; Berglund, Göran; Mattisson, Iréne; Hallmans, Göran; Palmqvist, Richard; Day, Nicholas E.; Khaw, Kay Tee; Key, Timothy J.; Hémon, Bertrand; Saracci, Rodolfo; Kaaks, Rudolf; Riboli, Elio

doi:10.1093/jnci/dji164

Cited by 706 publications

(498 citation statements)

References 40 publications

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“…At older ages, dietary factors affect colorectal cancer risk (Norat et al, 2005), but whether this relates to regional differences in incidence among TYAs is unknown. Cancer represents a major source of morbidity and mortality in 13 -24 year olds.…”

Section: Discussionmentioning

confidence: 99%

Cancer incidence patterns by region and socioeconomic deprivation in teenagers and young adults in England

et al. 2007

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Data on 35 291 individuals with cancer, aged 13 -24 years, in England from 1979 to 2001 were analysed by region and socioeconomic deprivation of census ward of residence, as measured by the Townsend deprivation index. The incidence of leukaemia, lymphoma, central nervous system tumours, soft tissue sarcomas, gonadal germ cell tumours, melanoma and carcinomas varied by region (Po0.01, all groups) but bone tumour incidence did not. Lymphomas, central nervous system tumours and gonadal germ cell tumours all had higher incidence in less deprived census wards (Po0.01), while chronic myeloid leukaemia and carcinoma of the cervix had higher incidence in more deprived wards (Po0.01). In the least deprived wards, melanoma incidence was nearly twice that in the most deprived, but this trend varied between regions (Po0.001). These cancer incidence patterns differ from those seen in both children and older adults and have implications for aetiology and prevention.

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Section: Discussionmentioning

confidence: 99%

Cancer incidence patterns by region and socioeconomic deprivation in teenagers and young adults in England

et al. 2007

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“…Zwischen dem Verzehr von Geflügel und/oder -produkten besteht keine positive Korrelation [46]. Die positive Assoziation wird am ehesten durch die Verarbeitung und die Zubereitungsart verursacht, wie Daten des Prostate, Lung, Colorectal, and Ovarian cancer trials zeigen.…”

Section: Level Of Evidence 2aunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

151

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“…Epidemiological studies suggest that high fish intake is associated with a decreased risk of colorectal cancer (2,3,7). Most of the beneficial effects have been linked to the high content of the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in some fish.…”

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confidence: 99%

Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cells

et al. 2009

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Epidemiological studies suggest that high fish intake is associated with a decreased risk of colorectal cancer which has been linked to the high content of the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA) in some fish. The aim of the study was to compare the modulation of gene expression in LT97 colon adenoma cells in response to EPA and DHA treatment. Therefore, we used custom-designed cDNA arrays containing probes for 306 genes related to stress response, apoptosis and carcinogenesis and hybridised them with cDNA from LT97 cells which were treated for 10 or 24 h with 50 lM EPA or DHA. There was a marked influence of n-3 PUFA on the expression of several gene types, such as detoxification, cell cycle control, signaling pathways, apoptosis and inflammation. DHA and EPA generally modulated different sets of genes, although a few common effects were noted. In our approach, we used preneoplastic adenoma cells which are a relevant model for target cells of chemoprevention. If verified with real time PCR, these results identify genes and targets for chemoprevention of colon cancer.

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Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition

Abstract: Our data confirm that colorectal cancer risk is positively associated with high consumption of red and processed meat and support an inverse association with fish intake.

Cited by 706 publications

References 40 publications

Cancer incidence patterns by region and socioeconomic deprivation in teenagers and young adults in England

Cancer incidence patterns by region and socioeconomic deprivation in teenagers and young adults in England

S3-Leitlinie – Kolorektales Karzinom

Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cells

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