2017
DOI: 10.1002/adhm.201601410
|View full text |Cite
|
Sign up to set email alerts
|

Mechanical Adaptability of the MMP‐Responsive Film Improves the Functionality of Endothelial Cell Monolayer

Abstract: Extracellular matrix and cells are inherent in coordinating and adapting to each other during all physiological and pathological processes. Synthetic materials, however, show rarely reciprocal and spatiotemporal responses to cells, and lacking self-adapting properties as well. Here, a mechanical adaptability based on the matrix metalloproteinase (MMPs) sensitive polyelectrolyte film is reported. Poly-lysine (PLL) and methacrylated hyaluronic acid (HA-MA) nanolayers are employed to build the thin film through t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
25
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
7

Relationship

5
2

Authors

Journals

citations
Cited by 33 publications
(26 citation statements)
references
References 53 publications
1
25
0
Order By: Relevance
“…What’s more, higher biglycan expression of oriented EC monolayer may also contribute to the process. Biglycan, as one of heparin sulfate proteoglycans, acts as a cofactor for thrombin to inhibit activation of several coagulant factors . In addition, aggregated and activated platelets provide procoagulant surfaces and Li et al demonstrated that the orientation of ECs inhibited platelet adhesion and activation. , Although NO can inhibit coagulation as well, it seems that eNOS expression level of EC monolayer had no clear correlation with the activated coagulation time.…”
Section: Resultsmentioning
confidence: 99%
“…What’s more, higher biglycan expression of oriented EC monolayer may also contribute to the process. Biglycan, as one of heparin sulfate proteoglycans, acts as a cofactor for thrombin to inhibit activation of several coagulant factors . In addition, aggregated and activated platelets provide procoagulant surfaces and Li et al demonstrated that the orientation of ECs inhibited platelet adhesion and activation. , Although NO can inhibit coagulation as well, it seems that eNOS expression level of EC monolayer had no clear correlation with the activated coagulation time.…”
Section: Resultsmentioning
confidence: 99%
“…6 ) were observed. It was previously reported that soft substrate was in favor of VECs to generate autacoids and VSMCs to maintain contractile/differentiated phenotype [ 21 , 26 , 38 ]. We observed that VECs on soft substrate showed a higher level of autophagy and endothelial function compared with cells on stiff substrate.…”
Section: Discussionmentioning
confidence: 99%
“…Human liver cells were found to have a similar intracellular autophagic level on polydimethylsiloxane (PDMS) gels with stiffness varying from 11 to 1220 kPa, but the location and distribution of the autophagosomes exhibited stiffness-dependency [ 18 ]. Various investigations have been conducted to study how vascular cells behave in response to changing in substrate stiffness [ [19] , [20] , [21] , [22] ]. Previously, we have demonstrated that adhesion, migration and proliferation of VECs and VSMCs were reduced on the substrate with lower stiffness [ 20 , [23] , [24] , [25] , [26] ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Such a difference in the stiffness may be ascribed to different crosslinking densities since the multi-wavelength light leads to whole film crosslinking while the standing-wave light leads to part of the film. [18]…”
Section: Stratified Crosslinking Of the (Pei/paa-n 3 ) 5 Filmmentioning
confidence: 99%