Mechanical and biological properties of bioglass/magnesium composites prepared via microwave sintering route

Wan, Yizao; Cui, Teng; Li, Wei; Li, Chunzhi; Xiao, Jian; Zhu, Yong; Ji, Dehui; Xiong, Guangyao; Luo, Honglin

doi:10.1016/j.matdes.2016.03.096

Cited by 74 publications

(34 citation statements)

References 42 publications

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“…The ALP activity of MC3T3-E1 cells cultured on BC, CA, and BC/CA scaffolds for 7 and 14 days was measured using a BCIP/NBT alkaline phosphatase color development kit (Beyotime, China), following our previous procedure [30][31][32].…”

Section: Alkaline Phosphatase (Alp) Activity Assay and Alp Stainingmentioning

confidence: 99%

Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances

Luo

Gan

Gama

et al. 2020

Materials Science and Engineering: C

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Developing fibrous scaffolds with hierarchical structures that closely mimic natural extracellular matrix (ECM) is highly desirable. However, fabricating scaffolds with true nanofibers (< 100 nm) and submicrofibers (< 1 μm) remains a big challenge. In this work, to mimic the fibrillar structure of natural ECM, bacterial cellulose (BC) nanofibers were hybridized with cellulose acetate (CA) submicrofibers for the first time. The interpenetrated nano-submicron fibrous BC/CA scaffold was fabricated using the combined electrospinning and modified in situ biosynthesis method. The BC/CA scaffold has an integrated symmetrical nanostructure in which BC nanofibers (42 nm in diameter) penetrate into the submicrofibrous CA (820 nm in diameter) scaffold. The BC/CA scaffold shows an interconnected porous structure with a high porosity of > 90%. Additionally, the combination of CA submicrofibers with BC nanofibers leads to significantly improved mechanical properties over nanofibrous BC and submicrofibrous CA scaffolds and enlarged pores over nanofibrous BC scaffold. In addition, the biological behaviors of prepared BC/CA on MC3T3-E1 cells were investigated. Results suggested that BC/CA scaffold is beneficial for cell migration and proliferation. Moreover, the BC/CA scaffold shows higher alkaline phosphatase (ALP) activity, and calcium depositions. In addition, the hierarchical structures can effectively improve the expression of osteogenic gene (ALP mRNA and Runx2 mRNA) and protein (ALP). We believe that the methodology might provide biomimetic morphological microenvironments for enhanced tissue regeneration.

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Section: Alkaline Phosphatase (Alp) Activity Assay and Alp Stainingmentioning

confidence: 99%

Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances

Luo

Gan

Gama

et al. 2020

Materials Science and Engineering: C

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“…The deflocculant concentration was determined by deflocculation curve in a suspension with 60 wt% solid concentration. The use of this dispersant (Na 2 SiO 3 ) was due to the ease of being found in the market, since it is used in traditional ceramic industries [12,21,22], besides providing SiO 2 to the studied material that can contribute to the formation of bioglass on the surfaces of the particles, improving the osteoinductive effects of tricalcium phosphate [15][16][17]. The possibility of bioglass formation on the surface of the particles of TCP will be studied in future works.…”

Section: Methodsmentioning

confidence: 99%

“…The objective of this work was to obtain b-tricalcium phosphate parts, shaped by the replica method, supported by rheological concepts, to be used as grafting elements or even bone prostheses [11]. The use of the sodium silicate as dispersant in the studied suspensions is part of this work, since it can contribute to the formation of glassy phase (bioglass) on the surfaces of the TCP particles, improving osteoinductive effects [15][16][17]. The addition of processing additives in order to allow bioglass formation on the surface of biomaterials was found only for hydroxyapatite [18].…”

Section: Introductionmentioning

confidence: 99%

β-Tricalcium phosphate shaped by replica method

et al. 2019

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Biomaterials, such as tricalcium phosphate, can have different resorption rates in the organism that depend on their physicochemical properties, where the surface condition, such as morphology, size of particles and porosity, is important. In this work, we studied the coating of natural Luffa cylindrica matrix with β-tricalcium phosphate, using the dip replica forming method, in order to adjust the surface conditions to meet the demand of bone resorption. The materials were characterized in terms of specific surface area, particle shape, imaging in electronic scanning microscope, and zeta potential in water media. The suspensions used for coating of the matrices were produced with distilled water and sodium silicate as dispersant and carboxymethyl cellulose as a binder element. Rheological measurements were performed on rotational rheometer and viscometer. The products generated with 2.5 wt% of sodium silicate and 0.75 wt% of carboxymethyl cellulose, after sintering, had pore sizes consistent with high rates of reabsorption and porosity that suggest a future use as a biomaterial.

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“…As suspensões estudadas foram produzidas utilizando-se água destilada e o dispersante, silicato de sódio (Na 2 SiO 3 , Casa do Ceramista, Brasil), foi ajustado por meio de curva de defloculação em uma suspensão contendo 50% em massa de sólidos. Este dispersante (Na 2 SiO 3 ) foi escolhido por ser facilmente encontrado no mercado, uma vez que é utilizado em escala na produção de 'barbotinas' em indústrias cerâmicas tradicionais [8,12,13], além de fornecer SiO 2 ao material estudado que pode contribuir com a formação de fase vítrea (biovidro) nas superfícies, melhorando os efeitos osteoindutores da hidroxiapatita [14][15][16]. Esta última possibilidade, a da formação de biovidro na superfície das partículas de HA, será estudada em futuros trabalhos.…”

Section: Materiais E Métodosunclassified

Avaliação reológica da hidroxiapatita

et al. 2018

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Resumo Os biomateriais, como a hidroxiapatita (HA), podem apresentar diferentes taxas de reabsorção no organismo em função da patologia a ser tratada e são dependentes das propriedades físico-químicas do biomaterial, onde a condição superficial é de fundamental importância. Neste trabalho, buscou-se desenvolver um biomaterial à base de HA com o silicato de sódio (Na2SiO3) como dispersante e com potencial de formação de biovidro na superfície, além disso, conhecer as condições reológicas para se obter produtos adequados por conformação a úmido, via processamento coloidal. Caracterizou-se o material em termos da forma das partículas, observadas em microscópio, e área superficial específica. As medidas reológicas das suspensões utilizadas foram realizadas em reômetro rotacional. Observou-se a possibilidade de produção do biomaterial proposto, conformado em moldes porosos, através de suspensões com 2,0% em massa de silicato de sódio trabalhando-se preferencialmente em taxas de cisalhamento abaixo de 200 s-1.

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Mechanical and biological properties of bioglass/magnesium composites prepared via microwave sintering route

Cited by 74 publications

References 42 publications

Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances

Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances

β-Tricalcium phosphate shaped by replica method

Avaliação reológica da hidroxiapatita

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