Mechanical and drug-release properties of atenolol-Carbomer hydrophilic matrix tablets

Design Optimization and Evaluation of Gastric Floating Matrix Tablet of Glipizide

“…Comparatively much higher magnitude of k 1 vis-à-vis k 2 clearly shows that the drug release was predominantly Fickian diffusion, with a very little contribution of polymer relaxation. As viscosity of the gel layer around the tablet increased with an increase in the hydrogel concentration, it decreases the release of drug [31,32]. The gel formed during the penetration of dissolution medium into the matrix consisted of closely packed swollen particles, with more polymer amount, more thick gel formed inhibits dissolution medium penetration more strongly, and resulting in a reduction in the drug release values in 12 h indicating slower drug release.…”

Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery

“…Hydrophilic polymers like carbopol (CP) and polycarbophil (PCP) which show pH-dependent swelling behavior (pH > 7.0) have been investigated to prepare controlled release formulations with zero-order and near zero-order release kinetics (Perez-Marcos, Iglesias, & Gomez-Amoxa, 1991;Luessen et al, 1995). The pH-dependent swellability of these polymers can be explored for their ability to target drug release to the colon.…”

Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery

“…Hydrophilic polymers like carbopol (CP) and polycarbophil (PCP) which show pH dependent swelling behavior (pH > 7.0) have been investigated to prepare controlled release formulations with zero-order and near zero-order release kinetics (20,21). The pH dependent swellability of these polymers can be explored for their ability to target drug release to the colon.…”