Mechanical Characterization of Porcine Abdominal Organs

Poroviscoelastic Modeling of Liver Biomechanical Response in Unconfined Compression

“…However, upon examination of the percentage of the peak reaction force that can be predicted with 95% accuracy, the data compare favorably with other similar studies on biological tissue. 7,22,36 In future studies, a larger sample size may aid in narrowing confidence intervals.…”

“…Work by Miller 21 in 2000 used 3-D non-linear viscoelastic (VE) modeling; Tamura et al 36 conducted studies in 2002 using quasi-linear viscoelastic (QLV) modeling techniques; and in 2008, Sparks and Dupaix 35 modeled liver tissue using an amorphous polymer model. On the whole, prior high rate liver models fall under the category of phenomenological descriptions, such as QLV theory.…”

Quantifying dynamic mechanical properties of human placenta tissue using optimization techniques with specimen-specific finite-element models

“…Previous studies on mechanical properties of biological tissues, such as brain (Miller and Chinzei, 2002), liver (Tamura et al, 2002), and kidney (Snedeker et al, 2005), have demonstrated that material models can be developed by applying curve-fitting techniques to experimental data. However, this approach requires testing with a uniform tissue specimen of known geometry, which is difficult to achieve with placenta tissue.…”

Sample, testing and analysis variables affecting liver mechanical properties: A review

“…However, freezing the tissue prior to testing caused a significant decrease of the failure strain. Tamura et al performed a series of preconditioning compression tests on porcine liver specimens to determine the effects of freezing on the mechanical response of the tissue [76]. Contrary to Santago and co-workers, they found that the hysteresis loops obtained after freezing samples matched those of the same samples before freezing, concluding that freezing did not significantly change the mechanical properties of the tissue in compression.…”

“…Significant decrease of failure strain after freezing (bovine liver) [79,80] No differences with respect to fresh tissue (porcine liver) [22,76,81] Preservation period Liver becomes stiffer and more viscous with increasing preservation time [15] Pre-strain Non-linear increase of storage and loss moduli with compressive pre-strain [42,70] Pre-stress Pre-stressed samples exhibit increased stiffness and decreased relaxation times [23] Gravity Significant sample pre-load resulting in non-uniform deformation field at the sample centre [17] behaviour and, along with testing and analysis variables, the resultant mechanical properties. We suggest that it is the combinatorial effect of the testing, modelling and sample variables which has resulted in the wide range of hepatic tissue mechanical properties reported in the literature.…”