Mechanical Forces Regulate Asymmetric Vascular Cell Alignment

Cui, Xin; Tong, Jie; Yau, Jimmy; Bajpai, Apratim; Yang, Jing; Peng, Yansong; Singh, Mrinalini; Qian, Weiyi; Ma, Xiao; Chen, Weiqiang

doi:10.1016/j.bpj.2020.09.020

Cited by 4 publications

(2 citation statements)

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“…S5), and found that a COM reaction coordinate can best mesh together the MD to BD scales. Additionally, it will be important in the future for our thermokinetic model to include minus end dynamics as another way to validate our modeling results as well as long-range effect of neighbors 38 (without ad hoc parametrization) and the seam interactions 64 to investigate their potential effects on the interaction energies.…”

Section: Discussionmentioning

confidence: 99%

Atomistic Basis of Microtubule Dynamic Instability Assessed Via Multiscale Modeling

Hemmat

Odde

2021

Ann Biomed Eng

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Microtubule “dynamic instability,” the abrupt switching from assembly to disassembly caused by the hydrolysis of GTP to GDP within the β subunit of the αβ-tubulin heterodimer, is necessary for vital cellular processes such as mitosis and migration. Despite existing high-resolution structural data, the key mechanochemical differences between the GTP and GDP states that mediate dynamic instability behavior remain unclear. Starting with a published atomic-level structure as an input, we used multiscale modeling to find that GTP hydrolysis results in both longitudinal bond weakening (~ 4 kBT) and an outward bending preference (~ 1.5 kBT) to both drive dynamic instability and give rise to the microtubule tip structures previously observed by light and electron microscopy. More generally, our study provides an example where atomic level structural information is used as the sole input to predict cellular level dynamics without parameter adjustment.

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Section: Discussionmentioning

confidence: 99%

Atomistic Basis of Microtubule Dynamic Instability Assessed Via Multiscale Modeling

Hemmat

Odde

2021

Ann Biomed Eng

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“…Changes in mechanical forces, such as stretch or shear stress, induce adjustments in the structure of the vessel wall to accommodate the changed conditions and ultimately return the tensile and shear stresses to their original levels [35,36]. Transient changes in vessel width occur as a result of acute changes in mechanical stress.…”

Section: Interaction Between Hemodynamic Forces Vascular Structure An...mentioning

confidence: 99%

Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro

Katoh

2023

IJMS

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Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mechanical stresses, both in situ and in vitro, affect endothelial cells. We review the basic principles underlying the cellular response to mechanical stresses. We also consider the implications of these findings for understanding the mechanisms of mechanotransducer and mechano-signal transduction systems by cytoskeletal components.

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