“…Large stones must be fragmented before they can be extracted by ML, which is the modality used most commonly, and complete bile duct clearance can be achieved in 80% to 90% of cases after ML is applied, regardless of whether EST, EPBD, or both are performed. [26][27][28][29] Also the main purpose of LBS in endotherapy for large bile duct stones is that additive endoscopic procedure steps, such as ML, are omitted to simplify the process of stone extraction and reduce the complications. Therefore, when researchers evaluate the efficacy of LBS as a treatment option for large bile duct stones, the precise definition of success for complete clearance of bile ducts should be complete retrieval of stones by using LBS alone without adding another step or procedure.…”