Mechanical, microstructural, and rheological characterization of gelatin-dialdehyde starch hydrogels constructed by dual dynamic crosslinking

Cui, Tianqi; Sun, Yu; Wu, Yue; Jiarong, Wang; Ding, Yangyue; Cheng, Jianjun; Guo, Mingruo

doi:10.1016/j.lwt.2022.113374

Cited by 29 publications

(9 citation statements)

References 43 publications

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“…Conversely, the tensile strength, elongation at break and compressive strength of PVA hydrogels improved with longer freezing duration because of the increased crosslinking degree ( Figure 1 g–i). It is well-known that the crosslinking degree benefits mechanical strength because a higher crosslinking degree results in a denser hydrogel structure [ 12 , 25 , 26 ]. In addition to mechanical strength, the crosslinking degree affects hydrogel adhesion simultaneously.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

Kumar

et al. 2022

Gels

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The development of adhesive hydrogel materials has brought numerous advances to biomedical engineering. Hydrogel adhesion has drawn much attention in research and applications. In this paper, the study of hydrogel adhesion is no longer limited to the surface of hydrogels. Here, the effect of the internal crosslinking degree of hydrogels prepared by different methods on hydrogel adhesion was explored to find the generality. The results show that with the increase in crosslinking degree, the hydrogel adhesion decreased significantly due to the limitation of segment mobility. Moreover, two simple strategies to improve hydrogel adhesion generated by hydrogen bonding were proposed. One was to keep the functional groups used for hydrogel adhesion and the other was to enhance the flexibility of polymer chains that make up hydrogels. We hope this study can provide another approach for improving the hydrogel adhesion generated by hydrogen bonding.

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Section: Resultsmentioning

confidence: 99%

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

Kumar

et al. 2022

Gels

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“…However, the network structure of gelatin formed by hydrogen bonding is unstable. The network becomes destroyed as the temperature rises above the gel temperature, resulting in poor thermal and low mechanical properties ( Cui et al, 2022 ). Moreover, materials made of gelatin in the dry state show brittleness, low flexibility, and extremely fast degradation rate problems ( Chang et al, 1998 ; Tan et al, 2009 ; Gorgieva and Kokol, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

A study on the material properties of novel PEGDA/gelatin hybrid hydrogels polymerized by electron beam irradiation

Raman

Kuehnert²,

Daikos³

et al. 2023

Front. Chem.

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Gelatin-based hydrogels are highly desirable biomaterials for use in wound dressing, drug delivery, and extracellular matrix components due to their biocompatibility and biodegradability. However, insufficient and uncontrollable mechanical properties and degradation are the major obstacles to their application in medical materials. Herein, we present a simple but efficient strategy for a novel hydrogel by incorporating the synthetic hydrogel monomer polyethylene glycol diacrylate (PEGDA, offering high mechanical stability) into a biological hydrogel compound (gelatin) to provide stable mechanical properties and biocompatibility at the resulting hybrid hydrogel. In the present work, PEGDA/gelatin hybrid hydrogels were prepared by electron irradiation as a reagent-free crosslinking technology and without using chemical crosslinkers, which carry the risk of releasing toxic byproducts into the material. The viscoelasticity, swelling behavior, thermal stability, and molecular structure of synthesized hybrid hydrogels of different compound ratios and irradiation doses were investigated. Compared with the pure gelatin hydrogel, 21/9 wt./wt. % PEGDA/gelatin hydrogels at 6 kGy exhibited approximately up to 1078% higher storage modulus than a pure gelatin hydrogel, and furthermore, it turned out that the mechanical stability increased with increasing irradiation dose. The chemical structure of the hybrid hydrogels was analyzed by Fourier-transform infrared (FTIR) spectroscopy, and it was confirmed that both compounds, PEGDA and gelatin, were equally present. Scanning electron microscopy images of the samples showed fracture patterns that confirmed the findings of viscoelasticity increasing with gelatin concentration. Infrared microspectroscopy images showed that gelatin and PEGDA polymer fractions were homogeneously mixed and a uniform hybrid material was obtained after electron beam synthesis. In short, this study demonstrates that both the presence of PEGDA improved the material properties of PEGDA/gelatin hybrid hydrogels and the resulting properties are fine-tuned by varying the irradiation dose and PEGDA/gelatin concentration.

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“…Cui et al [ 167 ] described preparing gelatin hydrogels that were chemically cross-linked with the dialdehyde starch. The authors used a 10% ( w / v ) gelatin solution and a 10% ( w / v ) dialdehyde starch solution in an amount between 1 and 4 mL.…”

Section: Cross-linking Agents From Synthetic and Natural Sourcesmentioning

confidence: 99%

“…Furthermore, an increase in the content of the dialdehyde starch reduced the size and number of pores and smoothed the material surface. Cui et al [ 167 ] found that increasing the content of the cross-linking agent decreased the swelling speed but increased its stability.…”

Section: Cross-linking Agents From Synthetic and Natural Sourcesmentioning

confidence: 99%

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

2023

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The main aim of this review is to assess the potential use of natural cross-linking agents, such as genipin, citric acid, tannic acid, epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for the biomedical, pharmaceutical, and cosmetic industries. Chemical cross-linking is one of the most important methods that is commonly used to form mechanically strong hydrogels based on biopolymers, such as alginates, chitosan, hyaluronic acid, collagen, gelatin, and fibroin. Moreover, the properties of natural cross-linking agents and their advantages and disadvantages are compared relative to their commonly known synthetic cross-linking counterparts. Nowadays, advanced technologies can facilitate the acquisition of high-purity biomaterials from unreacted components with no additional purification steps. However, while planning and designing a chemical process, energy and water consumption should be limited in order to reduce the risks associated with global warming. However, many synthetic cross-linking agents, such as N,N’-methylenebisacrylamide, ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylates, epichlorohydrin, and glutaraldehyde, are harmful to both humans and the environment. One solution to this problem could be the use of bio-cross-linking agents obtained from natural resources, which would eliminate their toxic effects and ensure the safety for humans and the environment.

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Mechanical, microstructural, and rheological characterization of gelatin-dialdehyde starch hydrogels constructed by dual dynamic crosslinking

Cited by 29 publications

References 43 publications

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

A study on the material properties of novel PEGDA/gelatin hybrid hydrogels polymerized by electron beam irradiation

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

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