Mechanical properties and bioactivity of porous PLGA/TiO2 nanoparticle-filled composites for tissue engineering scaffolds

Porous titanium for biomedical applications: An experimental study on rabbits

“…The porous surface titanium offers certain advantages over solid Ti, including enhancing bone-implant interface strength by promoting bone ingrowth and reducing the bone-implant modulus mismatch, which can lead to stress shielding. Therefore, biomaterials must exhibit hardness similar to bone (16), without producing a systemic or localized immune response (17). In addition, the material to be implanted must present mechanical properties adequate for the propose, while also presenting elasticity values similar to bone (17).…”

“…Therefore, biomaterials must exhibit hardness similar to bone (16), without producing a systemic or localized immune response (17). In addition, the material to be implanted must present mechanical properties adequate for the propose, while also presenting elasticity values similar to bone (17). The mechanical properties of titanium products made of PM depend on the material's composition, and on the density and final microstructure of the compact.…”

Nano-Doped Matrices for Tissue Regeneration

“…The authors finally proposed that the piezoelectric properties of such composites may provide the stimulatory cues necessary to promote neural cell function. (Zhang et al, 2007) and (Torres et al, 2007). Reproduced with permission from Elsevier…”

“…The number and size of Ag nanoparticle on the matrix surface was found to continuously increase with the irradiation time, and that the particles with an average size of 21 nm exhibited a strong antimicrobial activity. Specific applications for bone tissue engineering were described by some works in 2006 and 2007, reporting the results obtained by fabricating doped matrices and testing their biological activity by immersing them in standard culture media and simulated body fluid (SBF), or evaluating their in vitro response with osteoblasts-like cells or with human mesenchymal stem cells (hMSCs) (Li et al, 2006;Gerhardt et al, 2007;Sui et al, 2007;Torres et al, 2007;Zhang et al, 2007). The first example of Li et al is constituted by electrospun silk fibroin scaffolds containing bone morphogenetic protein 2 (BMP-2) and nanoparticles of hydroxyapatite.…”

Advances in Regenerative Medicine

“…The authors finally proposed that the piezoelectric properties of such composites may provide the stimulatory cues necessary to promote neural cell function. and (Torres et al, 2007). Reproduced with permission from Elsevier…”