Porous titanium for biomedical applications: An experimental study on rabbits

Vasconcellos, Luana Marotta Reis de; Leite, Daniel de Oliveira; Nascimento, Fernanda Oliveira; Vasconcellos, Luis Gustavo Oliveira de; Graça, Mario Lima de Alencastro; Carvalho, Yasmin Rodarte; Cairo, Carlos Alberto Alves

doi:10.4317/medoral.15.e407

Cited by 37 publications

(42 citation statements)

References 17 publications

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“…The micropores are formed due to partial sintering and incomplete densification of the powder particles. The true densities of the foams were found to be equal to 4.55 g/cm 3 . The total volume percentage of pores for the foams produced was equal to 61.25%±0.29.…”

Section: Results and Discussion Figure 2 Transverse Cross-section Bementioning

confidence: 92%

“…The densities of the powders were measured using a helium pycnometer (AccuPyc II 1340, Micromeritics, USA) with a filling pressure of 10 psi over 10 cycles. The estimated densities were 4.5 and 1.98 g/cm 3 for the Ti powder and KCl respectively. The morphologies of the powder particles are shown in Figure 1 .The binder used in this study was a multi-polymer system that consists of PEG1500, Poly methyl methacrylate (PMMA) and stearic acid.…”

Section: Starting Materials and Feedstock Preparationmentioning

confidence: 93%

“…This inhomogeneity in load transfer occurs due to the large difference between the elastic moduli of the dense implant and the surrounding tissue or bone, where the dense material of the implant carries stresses without transmitting them into the bone, thus shielding it and leading to its disintegration in the body environment. The presence of pores in the structure of the foams can solve this and also promote bone ingrowth as well as cell attachment and consequently, improve the osseo-integration of these implants [3]. Although the optimum size of pores for bone ingrowth is still under debate, several studies reported that the ideal size range is about 100-400 µm [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Open pore titanium foams via metal injection molding of metal powder with a space holder

Shbeh

Goodall

2016

Metal Powder Report

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Section: Results and Discussion Figure 2 Transverse Cross-section Bementioning

confidence: 92%

Section: Starting Materials and Feedstock Preparationmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Open pore titanium foams via metal injection molding of metal powder with a space holder

Shbeh

Goodall

2016

Metal Powder Report

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“…Most OP insecticides are moderately lipophilic and after acute exposure, a small percentage can accumulate in fat stores [9]. Cases have been reported of other OP insecticides, such as fenthion, that have caused delayed cholinergic crisis after unmetabolized compounds from adipose tissue have been mobilized back into the vascular compartment [10][11][12].…”

Section: Urinary Elimination Kinetics Of Apmentioning

confidence: 99%

Urinary elimination kinetics of acephate and its metabolite, methamidophos, in urine after acute ingestion

et al. 2009

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INTRODUCTIONAcephate (AP) is one of the few commercially available, over-thecounter organophosphorus (OP) insecticides in the US. It is considered one of the safest OP insecticides because of its low mammalian toxicity, with a lethal dose (LD50) of 360 mg/kg in mice and 900 mg/kg in rats [1]. The selective toxicity of AP is due reportedly to differential bioactivation and metabolism in insects compared to mammals; however, the exact mechanism is still unknown. In insects, AP is rapidly and extensively metabolized to a more potent OP insecticide-methamidophos (MP)-which has a lower LD50 of 14-30 mg/kg in mice and rats, thus Keywords: Acephate, methamidaphos, toxicokinetics, urine, poisoning Notes: This work was funded, in whole, by internal operating funds of the Centers for Disease Control and Prevention. There was no outside funding of any kind used for this study. ABSTRACTIntroduction: Acephate (AP) is a widely available organophosphorus (OP) insecticide considered to have low mammalian toxicity. In plants and insects, AP is metabolized extensively to methamidophos (MP), a more potent OP insecticide. The limited mammalian metabolism of AP to MP has been studied in laboratory rat models and suggests that initial formation of MP from AP may inhibit further formation. No case reports of human ingestion with urine AP and MP levels have been previously published.Case Report: A 4-year-old male being evaluated for altered mental status and head trauma was noted to have muscarinic and nicotinic cholinergic signs. Further history suggested possible ingestion of a commercial AP product at an unknown time. Ingestion of AP was confirmed by the presence of urinary AP and MP and severely depressed red blood cell (RBC) cholinesterase and pseudocholinesterase activity levels. The patient initially received atropine in two 0.02 mg/kg IV boluses, then was started on 0.05 mg/kg IV per hour and titrated accordingly to clinical signs of cholinergic toxicity. Pralidoxime was also given at 20 mg/kg IV bolus, followed by an infusion of 10 mg/kg per hour. The patient required mechanical ventilation for 18 days and atropine infusion for 20 days. After a complicated intensive care unit course, he recovered and was discharged after a total of 32 days of hospitalization.Methods: Four urine samples collected at different times were analyzed for AP and MP by using high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Kinetic calculations were performed by using standard equations.Results: Suspected ingestion was confirmed by the presence of AP and MP in urine. The amount of MP found in urine suggests some limited human metabolism to this more toxic compound.Conclusions: Urinary elimination kinetics of AP demonstrates low metabolic conversion of AP to MP in humans.

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“…Currently, implant dentistry focuses on studies that address and enable more rapid osseointegration of implants for orthopedic and dental use, in an attempt to reduce or even eliminate the period of bone healing free from functional load [2]. Among the various lines of research oriented toward this purpose, the topographical characteristics of the implant surface at the bone-implant interface are considered relevant due to the strong influence on the quality of osseointegration achieved [3][4][5][6][7][8], together with the characteristics of the biomaterial from which the implant is produced [3,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Porous Titanium by Powder Metallurgy for Biomedical Application: Characterization, Cell Citotoxity and in vivo Tests of Osseointegration

Vasconcellos¹,

Carvalho²,

Prado³

et al. 2012

Biomedical Engineering - Technical Applications in Medicine

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Porous titanium for biomedical applications: An experimental study on rabbits

Cited by 37 publications

References 17 publications

Open pore titanium foams via metal injection molding of metal powder with a space holder

Open pore titanium foams via metal injection molding of metal powder with a space holder

Urinary elimination kinetics of acephate and its metabolite, methamidophos, in urine after acute ingestion

Porous Titanium by Powder Metallurgy for Biomedical Application: Characterization, Cell Citotoxity and in vivo Tests of Osseointegration

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