Mechanical properties and cytotoxicity of PLA/PCL films

Abstract

Thermodynamically immiscible poly(lactic acid) (PLA) and poly(e-caprolactone) (PCL) were blended and solution-cast by adding the 3% compatibilizer (tributyl citrate, TBC) of the PCL weight. In the PLA/PCL composition range of 99/1-95/ 5 wt%, mechanical properties of the PLA/PCL films with TBC were always superior to those of the films without TBC. The tensile strength of 42.9 ± 3.5 MPa and the elongation at break of 10.3 ± 2.7% were observed for the 93/7 PLA/PCL films without TBC, indicating that PCL addition is effective for strength and ductility. However, the tensile strength of 54.1 ± 3.4 MPa and the elongation at break of 8.8 ± 1.8% were found for the 95/5 PLA/PCL with TBC, indicating that the effect of co-addition of PCL and TBC on mechanical properties of the films is more pronounced. No cytotoxicity was observed for the PLA/PCL films regardless of TBC addition.

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

“…Between two formulations, PCL/PVP 95:5 was more resistant; hence, at a greater content of PCL, better mechanical properties can be found in the samples. As reported by Jeong et al [49], PCL addition improved the elasticity of PLA films, as can be observed in Figure 5, PCL/PVP 95:5 sample presented a major elastic range and a higher elastic deformation in comparison with PCL/PVP 85:15 sample.…”

Effect of polyethylene glycol molecular weight on cell growth behavior of polyvinyl alcohol/carboxymethyl cellulose/polyethylene glycol hydrogel

“…The specimen with a diameter of 15 mm and a thickness of 5 mm was fabricated and the strength was determined at a point where the specimen thickness decreased by 50%. [5,13] The strength of each sample was tested at least five times.…”

“…Detailed experimental procedures are described elsewhere. [4,5,[13][14][15][16][17][18][19][20][21] Cell counting kit-8 (CCK-8, Dojindo Molecular Technologies, Inc., Rockville, MD, USA) is used for the assay of cell proliferation. CCK-8, being nonradioactive, allows sensitive colorimetric assays for the determination of the number of viable cells in cell proliferation.…”

“…[1] Porous hydrogel scaffolds interconnected by physical and chemical bonds play a pivotal role in tissue engineering, making porosity suitable for cell ingrowth, water or biological fluid holding capacity, and new tissue formation as well as nutrient and oxygen transport. [1][2][3][4][5][6][7][8][9][10][11][12] Hydrogel as skin regeneration scaffold has attracted immediate attention due to their effective healing properties of various tissues, extensive vasculature, lymphatic system, nerve bundles, and softness. [2][3][4][5][6][7]11] In the skin rehabilitation market, a cheap and reliable scaffold for fast healing wound dressing is greatly demanded.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12] Hydrogel as skin regeneration scaffold has attracted immediate attention due to their effective healing properties of various tissues, extensive vasculature, lymphatic system, nerve bundles, and softness. [2][3][4][5][6][7]11] In the skin rehabilitation market, a cheap and reliable scaffold for fast healing wound dressing is greatly demanded. [2] Appropriate mechanical property, pore size, cost, and biocompatibility of the hydrogels can be adjusted by alloying natural and synthetic polymers.…”