Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications

Zhao, Lichen; Zhang, Zhe; Song, Yuting; Liu, Shuangjin; Qi, Yongfeng; Wang, Xin; Wang, Qingzhou; Cui, Chunxiang

doi:10.1016/j.matdes.2016.06.080

Cited by 93 publications

(28 citation statements)

References 47 publications

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“…Pure zinc metal, therefore, exhibits moderate degradation rates (faster than the slowly degrading Fe and its alloys, but slower than the rapidly degrading Mg and its alloys) due to passive layers of moderate stability, formed by corrosion products [19,[39][40][41].…”

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confidence: 99%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

240

124

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Abstract:In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn 2+ , is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn 2+ released from an implant may suppress harmful smooth muscle cells and restenosis in arteries, while stimulating beneficial osteogenesis in bone. An important limitation of pure zinc as a potential biodegradable structural support, however, lies in its low strength (σ UTS~3 0 MPa) and plasticity (ε < 0.25%) that are insufficient for most medical device applications. Developing high strength and ductility zinc with sufficient hardness, while retaining its biocompatibility, is one of the main goals of metallurgical engineering. This paper will review and compare the biocompatibility, corrosion behavior and mechanical properties of pure zinc, as well as currently researched zinc alloys.

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mentioning

confidence: 99%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

240

124

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“…Zn has been used as a single construction material for stents [98,102,105,106] and scaffolds [107] (Figure 4c), or used as an alloying material when combined with Mg [87,108] or Ca [109] . Applications of Zn in bioresorbable electronics range from electrodes [38,110] for batteries and sensors to micro/nano fillers [111] for conductive pastes (Figure 4d).…”

Section: Znmentioning

confidence: 99%

Bioresorbable Materials and Their Application in Electronics

Huang

2017

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Bioresorbable electronics that can dissolve away in aqueous environments and generate biologically safe products offers revolutionary solutions for replacing current built-to-last electronics predominantly used in implanted devices and electronic gadgets. Its contribution involves reducing the risk of surgical complications by minimizing the number of surgeries required and preventing the production of electronic waste by allowing rapid device recycling. This text presents bioresorbable materials (e.g. metals, polymers, inorganic compounds, and semiconductors) that have been used to construct electronic devices and analyzes their unique dissolution behaviors and biological effects. These materials are combined to yield representative devices including passive and active components and functional systems.

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“…First, as the chemical potential of Zn falls between the chemical potential values of Mg and Fe, it is expected to exhibit an intermediate rate of biodegradation, as compared to the extreme cases of Mg and Fe. [16][17][18][19] Second, the biodegradation process of Zn does not generate hydrogen gas. Finally, similar to Mg but unlike Fe, the biodegradation products of Zn are biocompatible.…”

Section: Introductionmentioning

confidence: 99%