Mechanical properties and thermal behaviour of PEGDMA hydrogels for potential bone regeneration application

Killion, John A.; Geever, Luke M.; Devine, Declan M.; Kennedy, James E.; Higginbotham, Clement L.

doi:10.1016/j.jmbbm.2011.04.004

Cited by 99 publications

(64 citation statements)

References 44 publications

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“…The prepared hydrogels exhibited absorption bands characteristic of DMA, along with bands characteristic of PEG, prior to exposure to water and the addition of cross-linking agents. On cross-linking, the DMA C=C bands were extinguished and the C=O band was shifted to greater wavenumbers, and the PEG bands were unaltered as observed in similar hydrogel materials 27–30 . Subsequent hydration of the cross-linked gel to reach equilibrium swelling in water, followed by dehydration, and then rehydration, did not alter the absorption bands associated with either PEG or DMA.…”

Section: Materials and Methods†mentioning

confidence: 65%

“…Phase separation in hydrogels gives rise to heterogeneity at length scales much greater than those observed in the scattering experiments. The cloudy appearance of the gel solutions and cross-linked gels indicates light scattering by interfaces between polymer-rich and polymer-poor regions much greater in size than the wavelength of visible light 19, 25–27 . It seems likely then that the mechanical heterogeneity observed here is linked to the structural heterogeneity associated with the phase-separated structure.…”

Section: Resultsmentioning

confidence: 99%

“…The cloudiness increased as cross-linking proceeded such that the resultant gels were opaque. This loss in clarity was interpreted as evidence that the hydrogels had undergone both solution induced phase separation 24, 25 on initial mixing and polymerization induced phase separation during crosslinking 19, 26, 27 ; the gels were thus expected to exhibit heterogeneous mechanical and transport properties.…”

Section: Materials and Methods†mentioning

confidence: 99%

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Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

et al. 2015

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Colloidal-probe spherical indentation load-relaxation experiments with a probe radius of 3 μm are conducted on poly(ethylene glycol) (PEG) hydrogel materials to quantify their steady-state mechanical properties and time-dependent transport properties via a single experiment. PEG-based hydrogels are shown to be heterogeneous in both morphology and mechanical stiffness at this scale; a linear-harmonic interpolation of hyperelastic Mooney-Rivlin and Boussinesq flat-punch indentation models was used to describe the steady-state response of the hydrogels and determine upper and lower bounds for indentation moduli. Analysis of the transient load-relaxation response during displacement-controlled hold periods provides a means of extracting two time constants τ1 and τ2, where τ1 and τ2 are assigned to the viscoelastic and poroelastic properties, respectively. Large τ2 values at small indentation depths provide evidence of a non-equilibrium state characterized by a phenomenon that restricts poroelastic fluid flow through the material; for larger indentations, the variability in τ2 values decreases and pore sizes estimated from τ2 via indentation approach those measured via macroscopic swelling experiments. The contact probe methodology developed here provides a means of assessing hydrogel heterogeneity, including time-dependent mechanical and transport properties, and has potential implications in hydrogel biomedical and engineering applications.

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Section: Materials and Methods†mentioning

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Materials and Methods†mentioning

confidence: 99%

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Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

et al. 2015

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“…This increase in gel fraction is linked to the increase in molecular weight of PEGDMA. Killion et al [29] has shown single polymer hydrogels of PEGDMA 600 to have a higher gel fraction than those of PEGDMA 400 [29].…”

Section: Gel Fraction Measurementmentioning

confidence: 99%

“…Highly crosslinked hydrogels have previously been prepared through photopolymerisation [29]. Similarly, the hydrogels investigated in this study were prepared by freeradical polymerisation using ultraviolet (UV) light.…”

Section: Hydrogel Synthesismentioning

confidence: 99%

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

et al. 2012

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Hydrogels formulated from single polymers are often insufficient in terms of their mechanical properties for use as bone substitute materials. Hence, hydrogels synthesised from combinations of polymers have been investigated to optimise the performance of such materials. In the current study, polypropylene glycol dimethacrylate was added to polyethylene glycol dimethacrylate of a variety of molecular weights and photopolymerised to form a series of hydrogels. Polyethylene glycol and polypropylene glycol have the same chemical structure with the exception of a methyl group on the later. Herein, the influence of the methyl group of polypropylene glycol on the mechanical properties of hydrogels for bone regeneration applications is reported. For both unconfined and cyclic compression testing, results demonstrated that the incorporation of PEGDMA into the precursor improves the compression strength of the hydrogels. For example, in unconfined compression tests the Young's modulus varied between 6.62 ± 0.31 MPa and 8.08 ± 0.81 MPa with the incorporation of PEGDMA 400.

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Developments in Hydrogel‐based Scaffolds and Bioceramics for Bone Regeneration

Stancu

Chappard

2019

Bioceramics and Biocomposites

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Mechanical properties and thermal behaviour of PEGDMA hydrogels for potential bone regeneration application

Cited by 99 publications

References 44 publications

Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

Developments in Hydrogel‐based Scaffolds and Bioceramics for Bone Regeneration

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