Mechanical properties of human coronary arteries

Claes, Els; Atienza, J. M.; Guinea, Gustavo V.; Rojo, Francisco Javier; Bernal, José Manuel López; Revuelta, José M.; Calafat, Manuel Elices

doi:10.1109/iembs.2010.5627560

Cited by 48 publications

(46 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the modulus of the model is closer to normal physiologic vessels than typical silicone models, allowing a feel and device deformation that are similar to those in a real clinical situation. 10,11 Here, we com-pare primary Stentriever thrombectomy with the aforementioned other modern thrombectomy approaches by using this in vitro model.…”

Section: Abbreviationsmentioning

confidence: 99%

Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model

Mokin¹,

Nagesh

Ionita

et al. 2014

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Abbreviationsmentioning

confidence: 99%

Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model

Mokin¹,

Nagesh

Ionita

et al. 2014

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…С другой стороны, полученные значения напряже-ния по Мизесу оказались существенно ниже преде-лов прочности, характерных для стенки корня аорты (1,4 МПа [14]), коронарных артерий (0,39-0,45 МПа [11]) и самих сосудистых графтов (2,44 и 3,54 МПа). Кроме того, предполагается, что используемый графт будет подвержен биодеградации с замещением собс-твенными тканями реципиента, что, возможно, поз-волит нивелировать исходные различия в свойствах до накопления существенных циклических дефор-маций.…”

Section: Discussionunclassified

“…Для построения моделей корня аорты и учас-тка коронарного русла использовали данные МСКТ ангиографии пациента М., 54 года. При описании элементов корня аорты использовали нелинейные полиномиальные модели II порядка [10,11]. Для моделирования физиологического давления выбра-ли два варианта графтов -PCL/VEGF и PHBV/PCL/ VEGF с последующей оценкой напряженно-дефор-мированного состояния.…”

Section: материалы и методыunclassified

Biomechanical Remodeling of Biodegradable Small-Diameter Vascular Grafts in Situ

Глушкова

Sevost'yanova

Антонова

et al. 2016

RJTAO

View full text Add to dashboard Cite

Aim: to evaluate the biomechanical remodeling of polymer grafts modified with vascular endothelial growth factor (VEGF) after implantation into rat abdominal aorta.Materials and methods. Vascular grafts of2 mmdiameter were fabricated by electrospinning from polycaprolactone (PCL) and a mixture of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) and PCL. The grafts were modified with VEGF by biphasic electrospinning. Morphology of the grafts was assessed by scanning electron microscopy. Physico-mechanical properties of PCL and PHBV/PCL grafts were estimated using uniaxial tensile test and physiological circulating system equipped with state-of-theart ultrasound vascular wall tracking system. Physico-mechanical testing of PCL/VEGF and PHBV/PCL/VEGF was performed before and after implantation into rat abdominal aorta for 6 months. The modeling of coronary artery bypass grafting (CABG) was performed by finite element analysis for modified grafts.Results. Durability of PCL and PHBV/PCL grafts did not differ from that of human internal mammary artery; however, elasticity and stiffness of these grafts were higher compared to internal mammary artery. Viscoelastic properties of the grafts were comparable to those of native blood vessels. Modification of the grafts with VEGF reduced material stiffness. Six months postimplantation, PCL/VEGF and PHBV/PCL/VEGF were integrated with aortic tissue that induced changes in the physico-mechanical properties of the grafts similar to the native vessel. Biomechanical modeling confirmed the functioning of modified grafts in bypass position for CABG.Conclusion. PCL/VEGF and PHBV/PCL/VEGF grafts have satisfactory physico-mechanical properties and can be potentially used in the reconstruction of blood vessels.

show abstract

“…This is less than 10% of the breaking strength of the RCA wall, which has been known to be approximately 1 MPa [24]. However, the von Mises stress at the throat yields a very low value.…”

Section: Total Displacement and Von Mises Stress Of Flexible Wallmentioning

confidence: 99%

Fluid-Structure Interaction Analysis for Drug Transport in a Curved Stenotic Right Coronary Artery

Park¹

2016

JBM

View full text Add to dashboard Cite

A blockage of blood vessels resulting from thrombus or plaque deposit causes serious cardiovascular diseases. This study developed a computational model of blood flow and drug transport to investigate the effectiveness of drug delivery to the stenotic sites. A three-dimensional (3D) model of the curved stenotic right coronary artery (RCA) was reconstructed based on the clinical angiogram image. Then, blood flow and drug transport with the flexible RCA wall were simulated using the fluid structure interaction (FSI) analysis and compared with the rigid RCA wall. Results showed that the maximal total displacement and von Mises stress of the flexible RCA model are 2.14 mm and 92.06 kPa. In addition, the effective injecting time point for the best performance of drug delivery was found to be between 0 s and 0.15 s (i.e., the fluid acceleration region) for both rigid and flexible RCA models. However, there was no notable difference in the ratio of particle deposition to the stenotic areas between the rigid and flexible RCA models. This study will be significantly useful to the design of a drug delivery system for the treatment of the stenotic arteries by targeting drugs selectively to the stenotic sites.

show abstract

Mechanical properties of human coronary arteries

Cited by 48 publications

References 25 publications

Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model

Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model

Biomechanical Remodeling of Biodegradable Small-Diameter Vascular Grafts in Situ

Fluid-Structure Interaction Analysis for Drug Transport in a Curved Stenotic Right Coronary Artery

Contact Info

Product

Resources

About