Mechanical properties of PNIPAM based hydrogels: A review

Haq, Muhammad Abdul; Su, Yunlan; Wang, Dujin

doi:10.1016/j.msec.2016.09.081

Cited by 519 publications

(385 citation statements)

References 205 publications

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“…39 NIPAM is one of the most frequently used monomers for the preparation of thermoresponsive polymers and was used in this work as the reference monomer. NPAM, the linear isomer of NIPAM, was selected on the basis that it could increase the overall hydrophobicity of the nanogels while keeping a similar monomer structure.…”

Section: Thermoresponsive Nanogelsmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N'-methylenebis (acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43°C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43°C, thus confirming the dual stimuli switch.

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Section: Thermoresponsive Nanogelsmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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“…[10][11][12][13][14] From extensive studies evaluating different properties of PAA hydrogels, such as swelling, 15 adhesion, 16 diffusion, 17 physico-chemical 18 and mechanical 19 properties, it has been revealed that the greatest concern about these types of hydrogels is their poor mechanical properties. 11,[20][21][22] The poor mechanical properties of PAA hydrogels, which relate closely to their large volume change subsequent to swelling, count as a marked weakness in consideration for adoption for high-tech applications, and have limited their specific applications. 23,24 Typically, PAA hydrogels exhibit a low Young's modulus (o200 kPa) and low fracture energy (o20 J m…”

Section: Introductionmentioning

confidence: 99%

In situ polymerized hyperbranched polymer reinforced poly(acrylic acid) hydrogels

Dehbari

Tavakoli

Khatrao

et al. 2017

Mater. Chem. Front.

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a Hydrogels have been extensively investigated for use in various applications. Poly acrylic acid (PAA) is a common example, which has been widely used due to its super hydrophilicity properties, biocompatibility and biodegradability characteristics. However its poor mechanical properties, which have been addressed in many research studies, are known as a drawback that limits its applications. So, enhancing PAA mechanical properties using a hyperbranched polymer (HB) is the key question to be addressed in this research.Investigations of the mechanical properties of the PAA-HB hydrogel revealed 130% improvement in the ultimate tensile strength, indicating a two times enhancement compared to that of PAA. Statistical analysis showed that the overall effect of introducing notches (with different depths) on the selected mechanical properties of both PAA and PAA-HB was significant. Mechanical characterization of PAA-HB networks showed that significant improvement in the mechanical properties was achieved as the capability of water uptake increased by 20%. Characterization of the physical properties confirmed that participation of HB may form a PAA based hybrid material with good swelling properties. Those findings are attributed to the supramolecular structure of the HB, which can introduce physical entanglement between the PAA network structure and increase the crystallinity of the final hydrogel as compared to those from the PAA hydrogel.

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“…When the tumor volumes reached 70-90 mm 3 , 30 C57Bl/6 mice were randomized into 3 groups, and 30 F1 mice were also randomly separated into 3 groups.…”

Section: Methodsmentioning

confidence: 99%

“…One of the well-known and widely studied polymer is poly(N-isopropylacrylamide) (PNIPAM) because of its well defined structure and property specially its temperature response is closed to human body [3]. It is not cytotoxic for any of human cell lines even at high concentration, and its excretion occurred via urine and faeces [4,5].…”

Section: Introductionmentioning

confidence: 99%

Preclinical Evaluation of Antitumor Efficacy of a New Radiopharmaceutical Based on Thermoresponsive Carrier and Samarium-153

Петриев¹,

Tishchenko²,

Сморызанова³

et al. 2018

KEn

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This work is devoted to studying the in vivo antitumor efficacy of the new injection radiopharmaceutical based on thermoresponsive polymer and β − -emitting radionuclide samarium-153 ( 153 Sm-KARP-CheM).The study of in vivo antitumor efficacy was performed using mice F1 and C57Bl/6 with transplanted subcutaneously sarcoma S37 and melanoma B16, respectively. The animals received single intratumoral bolus injections of 37 MBq (1 mCi), or 18.5 MBq (0.5 mCi) of 153 Sm-KARP-CheM, or saline in a volume 0.1 ml. The efficacy of antitumor treatment was evaluated using tumor growth inhibition index (TGI, %) and increase of average life span (ILS, %).The most meaningful therapeutic efficacy after intratumoral injection of 153 Sm-KARP-

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Mechanical properties of PNIPAM based hydrogels: A review

Cited by 519 publications

References 205 publications

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

In situ polymerized hyperbranched polymer reinforced poly(acrylic acid) hydrogels

Preclinical Evaluation of Antitumor Efficacy of a New Radiopharmaceutical Based on Thermoresponsive Carrier and Samarium-153

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