Mechanical properties of porcine and human arteries: implications for coronary anastomotic connectors

Andel, Carolien J. van; Pistecky, Peter V.; Borst, Cornelius

doi:10.1016/s0003-4975(03)00263-7

Cited by 128 publications

(79 citation statements)

References 24 publications

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“…Based on the previous work of van Andel et al [30] that previously found that the variability between the properties of both human and porcine arteries from different hosts varies more than the properties of different vessels from the same host, we used mean carotid porcine experimental data obtained in our laboratory to fit the material parameters of the Equation (9). Figure 7 shows the experimental stress-stretch curves and the prediction of the model where good agreement is readily observed.…”

Section: Simulations On a 3d Patient-specific Geometrymentioning

confidence: 99%

Numerical framework for patient‐specific computational modelling of vascular tissue

Alastrué

Garía

Peña

et al. 2009

Numer Methods Biomed Eng

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SUMMARYAccurate determination of the biomechanical implications of vascular surgeries or pathologies on patients requires developing patient-specific models of the organ or vessel under consideration. In this regard, combining the development of advanced constitutive laws that mimic the behaviour of the vascular tissue with advanced computer analysis and medical imaging techniques provides a powerful tool for modelling vascular tissues on a patient-specific basis. A framework for developing patient-specific models of blood vessel geometries obtained from medical imaging techniques is presented. The multiplicative decomposition of the deformation gradient tensor is intensively combined with the finite element method in order to account for the residual stress present on those geometries. In addition, an algorithm to compensate the mismatching effect of the load on the medical images is also discussed. Hence, a residually stressed and geometrically consistent model of the patient is obtained. The general framework is demonstrated in a realistic geometry of a carotid bifurcation. The example presented in this work shows that the incorporation of the residual stress dramatically affects the circumferential stress field, homogenizing the distribution and reducing the stress gradient. It also demonstrates that not accounting for the residual stress on a patient-specific geometry can lead to a completely different deformed configurations.

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Section: Simulations On a 3d Patient-specific Geometrymentioning

confidence: 99%

Numerical framework for patient‐specific computational modelling of vascular tissue

Alastrué

Garía

Peña

et al. 2009

Numer Methods Biomed Eng

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“…The thickness of atherosclerotic human coronary arteries range from 0.56 to 1.25 mm, depending upon the location of the arteries on the surface of the heart [28]. For this reason, a thickness of 0.8 mm was chosen to represent the stenosed coronary artery with the atherosclerotic localised plaque.…”

Section: Model Geometrymentioning

confidence: 99%

Determination of the influence of stent strut thickness using the finite element method: implications for vascular injury and in-stent restenosis

Zahedmanesh

Lally

2009

Med Biol Eng Comput

122

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Many clinical studies, including the ISAR-STEREO trial, have identified stent strut thickness as an independent predictor of in-stent restenosis where thinner struts result in lower restenosis than thicker struts. The aim of this study was to more conclusively identify the mechanical stimulus for in-stent restenosis using results from such clinical trials as the ISAR-STEREO trial. The mechanical environment in arteries stented with thin and thicker strut stents was investigated using numerical modelling techniques. Finite element models of the stents used in the ISAR-STEREO clinical trial were developed and the stents were deployed in idealised stenosed vessel geometries in order to compare the mechanical environment of the vessel for each stent. The stresses induced within the stented vessels by these stents were compared to determine the level of vascular injury caused to the artery by the stents with different strut thickness. The study found that when both stents were expanded to achieve the same initial maximum stent diameter that the thinner strut stent recoiled to a greater extent resulting in lower luminal gain but also lower stresses in the vessel wall, which is hypothesised to be responsible for the lower restenosis outcome. This study supports the hypothesis that arteries develop restenosis in response to injury, where high vessel stresses are a good measure of that injury. This study points to a critical stress level in arteries, above which an aggressive healing response leads to in-stent restenosis in stented vessels. Stents can be designed to reduce stresses in this range in arteries using preclinical tools such as numerical modelling.

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“…By contrast, porcine arteries are considered waste tissue by abattoirs and so are readily available. But, their mechanical response differs due to the effects of disease and ageing and the differing properties between human and porcine tissue [4,5]. Thus the creation of a human diseased tissue model from healthy porcine aorta potentially would ameliorate the cost and complexity of medical device design.…”

Section: Introductionmentioning

confidence: 99%

Creating a model of diseased artery damage and failure from healthy porcine aorta

Noble

Smulders

Green

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.Creating a model of diseased artery damage and failure from healthy porcine aorta AbstractLarge quantities of diseased tissue are required in the research and development of new generations of medical devices, for example for use in physical testing. However, these are difficult to obtain. In contrast, porcine arteries are readily available as they are regarded as waste. Therefore, reliable means of creating from porcine tissue physical models of diseased human tissue that emulate well the associated mechanical changes would be valuable. To this end, we studied the effect on mechanical response of treating porcine thoracic aorta with collagenase, elastase and glutaraldehyde. The alterations in mechanical and failure properties were assessed via uniaxial tension testing. A constitutive model composed of the Gasser-Ogden-Holzapfel model, for elastic response, and a continuum damage model, for the failure, was also employed to provide a further basis for comparison [1,2]. For the concentrations used here it was found that: collagenase treated samples showed decreased fracture stress in the axial direction only; elastase treated samples showed increased fracture stress in the circumferential direction only; and glutaraldehyde samples showed no change in either direction. With respect to the proposed constitutive model, both collagenase and elastase had a strong effect on the fibre-related terms. The model more closely captured the tissue response in the circumferential direction, due to the smoother and sharper transition from damage initiation to complete failure in this direction. Finally, comparison of the results with those of tensile tests on diseased tissues suggests these treatments indeed provide a basis for creation of physical models of diseased arteries.

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Mechanical properties of porcine and human arteries: implications for coronary anastomotic connectors

Cited by 128 publications

References 24 publications

Numerical framework for patient‐specific computational modelling of vascular tissue

Numerical framework for patient‐specific computational modelling of vascular tissue

Determination of the influence of stent strut thickness using the finite element method: implications for vascular injury and in-stent restenosis

Creating a model of diseased artery damage and failure from healthy porcine aorta

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