Mechanical property and biocompatibility of silk fibroin–collagen type II composite membrane

Lin, Xianglong; Gao, Lilan; Li, Ruixin; Cheng, Wei; Zhang, Chunqiu; Zhang, Xizheng

doi:10.1016/j.msec.2019.110018

Cited by 35 publications

(24 citation statements)

References 28 publications

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“…Mechanical properties of the matrix offer essential support to cells and play a key role in the cells’ growth and differentiation, but this is only a transition stage of the material [ 56 ]. In order to observe the differences between dialdehyde starch and dialdehyde chitosan cross-linking materials, the mechanical resistance at room conditions (temperature, humidity) were tested.…”

Section: Resultsmentioning

confidence: 99%

Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

Grabska-Zielińska

Sionkowska

Olewnik-Kruszkowska

et al. 2021

IJMS

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The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

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Section: Resultsmentioning

confidence: 99%

Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

Grabska-Zielińska

Sionkowska

Olewnik-Kruszkowska

et al. 2021

IJMS

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“…Film-forming properties of collagen could be enhanced by binding collagen with other polymeric molecule and/or biopolymers [ 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ]. Collagen and its film-forming properties can be modified by blending with polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) [ 104 , 105 , 106 ].…”

Section: Collagen Blends For Cosmetic Applicationsmentioning

confidence: 99%

“…Some research showed the possibility of tailoring certain properties by changing component ratios, since different interactions occurred between the two macromolecules. Collagen film can be modified by the addition of elastin [ 114 ], keratin [ 115 ], silk fibroin [ 116 , 117 , 118 , 119 ], and hyaluronic acid [ 120 , 121 , 122 , 123 , 124 ]. In Figure 4 polymers and biopolymers used for artificial blending with collagen have been shown [ 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ].…”

Section: Collagen Blends For Cosmetic Applicationsmentioning

confidence: 99%

“…All of these film properties are very important in cosmetic applications [ 125 ]. Collagen blends with other polymers and/or biopolymers also reveal some potential for biomedical applications, for example for artificial skin, bones, membranes, hydrogels, and many other products [ 119 , 120 , 121 , 122 ].…”

Section: Collagen Blends For Cosmetic Applicationsmentioning

confidence: 99%

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Collagen Based Materials in Cosmetic Applications: A Review

et al. 2020

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This review provides a report on properties and recent advances in the application of collagen in cosmetics. Collagen is a structural protein found in animal organisms where it provides for the fundamental structural support. Most commonly it is extracted from mammalian and fish skin. Collagen has attracted significant academic interest as well as the attention of the cosmetic industry due to its interesting properties that include being a natural humectant and moisturizer for the skin. This review paper covers the biosynthesis of collagen, the sources of collagen used in the cosmetic industry, and the role played by this protein in cosmetics. Future aspects regarding applications of collagen-based materials in cosmetics have also been mentioned.

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“…Results showed that this scaffold mimicked 3D microenvironment and promoted the repair of injured spinal cord [ 13 ]. Our group constructed a type II collagen/silk fibroin scaffold with suitable morphology, physical stability and biological functionality to promote chondrocytes proliferation [ 14 ]. Consistent results were also obtained by other teams confirmed that such materials had a favorable effect on articular cartilage repair [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of different aperture-sized type I collagen/silk fibroin scaffolds on the proliferation and differentiation of human dental pulp cells

Jiang

Zhang

et al. 2021

Regenerative Biomaterials

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This study aimed at evaluate the effects of different aperture-sized type I collagen/silk fibroin (CSF) scaffolds on the proliferation and differentiation of human dental pulp cells (HDPCs). The CSF scaffolds were designed with 3D mapping software Solidworks. Three different aperture-sized scaffolds (CSF1–CSF3) were prepared by low-temperature deposition 3D printing technology. The morphology was observed by scanning electron microscope (SEM) and optical coherence tomography. The porosity, hydrophilicity and mechanical capacity of the scaffold were detected, respectively. HDPCs (third passage, 1 × 105 cells) were seeded into each scaffold and investigated by SEM, CCK-8, alkaline phosphatase (ALP) activity and HE staining. The CSF scaffolds had porous structures with macropores and micropores. The macropore size of CSF1 to CSF3 was 421 ± 27 μm, 579 ± 36 μm and 707 ± 43 μm, respectively. The porosity was 69.8 ± 2.2%, 80.1 ± 2.8% and 86.5 ± 3.3%, respectively. All these scaffolds enhanced the adhesion and proliferation of HDPCs. The ALP activity in the CSF1 group was higher than that in the CSF3 groups (P < 0.01). HE staining showed HDPCs grew in multilayer within the scaffolds. CSF scaffolds significantly improved the adhesion and ALP activity of HDPCs. CSF scaffolds were promising candidates in dentine-pulp complex regeneration.

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Mechanical property and biocompatibility of silk fibroin–collagen type II composite membrane

Cited by 35 publications

References 28 publications

Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

Collagen Based Materials in Cosmetic Applications: A Review

Effects of different aperture-sized type I collagen/silk fibroin scaffolds on the proliferation and differentiation of human dental pulp cells

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