Mechanical responses of the isolated cervix of the day-22 pregnant rat to field stimulation

Hollingsworth, Michael A.; Isherwood, Catherine N. M.

doi:10.1007/bf01917884

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…The increases observed in untreated pregnant rats in the present results confirm the observations of Harkness & Nightingale (1962) and Rundgren (1974). The cervix of the late pregnant rat contains smooth muscle which is capable of responding to prostaglandins, oxytocin and neurotransmitters, but on Day 22 maximal responses of spirally cut cervical strips were small relative to those of the uterine horn (Hollingsworth & Isherwood, 1978, 1979, perhaps due to the lower proportion of smooth muscle in the cervix (Harkness & Harkness, 1959). It is therefore reasonable to account for changes in the extensibility of the cervix mainly in terms of changes in the connective tissue.…”

Section: Discussionmentioning

confidence: 99%

The effects of oestradiol benzoate, progesterone, relaxin and ovariectomy on cervical extensibility in the late pregnant rat

Hollingsworth¹,

Isherwood²,

Foster³

1979

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Section: Discussionmentioning

confidence: 99%

The effects of oestradiol benzoate, progesterone, relaxin and ovariectomy on cervical extensibility in the late pregnant rat

Hollingsworth¹,

Isherwood²,

Foster³

1979

Reproduction

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“…For example, it has been shown that the excitatory cholinergic innervation represents the major motor component of the rat cervix (Hollingworth 1974;Hollingworth and Isherwood 1979;Owman 1985, 1987;Sato et al 1989), which is probably responsible for the "sphincter-locked" cervix during pregnancy. At parturition, the release of NPY and VIP from the cholinergic nerve fibres could contribute to the relaxant mechanisms necessary for passage of the foetus through the endocervical canal.…”

Section: Retrograde Tracing Combined With Immunocytochemistry For Vipmentioning

confidence: 99%

Coexpression of neuropeptide Y and vasoactive intestinal polypeptide in pelvic plexus neurones innervating the uterus and cervix in the rat

Houdeau

Boyer

Rousseau

et al. 1997

Cell and Tissue Research

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The present study investigates the distribution and coexpression of neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in neurones of the accessory ganglion (AG), hypogastric plexus (HP) and paracervical ganglion (PCG), which compose the pelvic plexus in the female rat. Nerve cell bodies immunoreactive for NPY and VIP represent 84% and 46% of the neurone population in the PCG, respectively, while immunoreactivity for each peptide is observed in about 90% of the AG and HP neurones. Adjacent sections immunostained for NPY and VIP, as well as the use of immunocytochemistry combined with in situ hybridization show that 92% of the VIP-containing neurones in the pelvic plexus also contain NPY. In addition, a retrograde tracing study performed in combination with immunocytochemistry demonstrates that pelvic plexus neurones project preferentially to the lower part of the uterus and to the cervix, and that about 95% of these projecting neurones contain VIP. Taken together, our findings indicate that in the female rat, neurones of the pelvic plexus projecting to the lower genital tract mainly coexpress VIP and NPY, and supply nerve fibres to the vascular and nonvascular smooth muscle in the uterocervical region. Since NPY and VIP exert distinct effects according to the target tissue, our results suggest that neurones coexpressing these peptides play important roles in the local regulation of the vascular bed and motor activity of the lower genital tract.

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“…Dramatic structural and functional changes occur in the rat cervix prior to parturition (Williams et al, 1982). These changes, collectively referred to as "cervical ripening" are controlled, at least partially, by prostaglandins (Hillier and Wallis, 1982;Theobald et al, 1982;Rath et al, 1982;Norstrom et al, 1983;Fuchs et al, 1983;Uldbjerg et al, 1983) and neurotransmitters (Hollingsworth, 1974;Hollingsworth and Isherwood, 1979).…”

mentioning

confidence: 99%

The effects of pelvic neurectomy on collagen in the cervix of the pseudopregnant rat

et al. 1984

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Bilateral section of the pelvic parasympathetic nerves (pelvic-neurectomy) on day 5 of pseudopregnancy had no effect on the wet weight of ovaries, uteri, and/or cervices, but at day 9 serum progesterone was reduced to approximately half that of sham-operated animals. Collagen in the cervix was visualized with picrosirius red staining under polarization microscopy. Pelvic neurectomy decreased the birefringence of Type 1 collagen in the cervix to less than half that of sham operated animals. The decreased birefringence, an index of the organization of collagen fibers, is believed to be attributable to reduced progesterone levels. Alternatively, the pelvic nerve may directly influence mucopolysaccharides or collagenolytic enzymes in the cervix.

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Mechanical responses of the isolated cervix of the day-22 pregnant rat to field stimulation

Cited by 6 publications

References 5 publications

The effects of oestradiol benzoate, progesterone, relaxin and ovariectomy on cervical extensibility in the late pregnant rat

The effects of oestradiol benzoate, progesterone, relaxin and ovariectomy on cervical extensibility in the late pregnant rat

Coexpression of neuropeptide Y and vasoactive intestinal polypeptide in pelvic plexus neurones innervating the uterus and cervix in the rat

The effects of pelvic neurectomy on collagen in the cervix of the pseudopregnant rat

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