Mechanical Stresses, Arterial Stiffness, and Brain Small Vessel Diseases

Okada, Yôko; Kohara, Katsuhiko; Ochi, Masayuki; Nagai, Takayuki; Tabara, Yasuharu; Igase, Michiya; Miki, Tetsuro

doi:10.1161/strokeaha.114.006539

Cited by 17 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study conducted in 1,296 Asian participants suggested that arterial stiffness measured by PWV was associated with parameters of arterial remodeling such as carotid circumferential wall tension and longitudinal shear stress that were also associated with WMH and SBI, indicating that these remodeling vascular mechanisms may be pivotal for development of cerebral small vessel disease. 31 Our cross-sectional study design precludes determination of causality, but our findings are consistent with the observations that extracranial carotid dilation results in greater pulsatility transmission in the setting of systemic arterial stiffening. 32 In fact, reduction in wave reflection associated with extracranial large vessels stiffness results in greater pulsatile power to the intracranial vessels leading to cerebral small vessel diseases.…”

Section: Resultssupporting

confidence: 85%

Relationship between carotid arterial properties and cerebral white matter hyperintensities

et al. 2017

View full text Add to dashboard Cite

Objective: Since arterial stiffness is a functional measure of arterial compliance and may be an important marker of cerebrovascular disease, we examined the association of carotid artery stiffness with white matter hyperintensity volume (WMHV) in a cross-sectional study of 1,166 strokefree participants.Methods: Carotid beta stiffness index (STIFF) was assessed by M-mode ultrasound of the common carotid artery and calculated as the ratio of natural log of the difference between systolic and diastolic blood pressure over STRAIN, a ratio of the difference between carotid systolic and diastolic diameter (DD) divided by DD. WMHV was measured by fluid-attenuated inversion recovery MRI. The associations of STIFF, DD, and STRAIN with WMHV were examined using linear regression after adjusting for sociodemographic, lifestyle, and vascular risk factors. Results:In a fully adjusted model, larger carotid DD was significantly associated with greater log-WMHV (b 5 0.09, p 5 0.001). STIFF and STRAIN were not significantly associated with WMHV. In adjusted analyses stratified by race-ethnicity, STRAIN (b 5 21.78, p 5 0.002) and DD (b 5 0.11, p 5 0.001) were both associated with greater log-WMHV among Hispanic participants, but not among black or white participants.Conclusions: Large carotid artery diameters are associated with greater burden of white matter hyperintensity (WMH) in this multiethnic population. The association between increased diameters, decreased STRAIN, and greater WMH burden is more pronounced among Hispanics. These associations suggest a potential important pathophysiologic role of extracranial large artery remodeling in the burden of WMH. Neurology ® 2017;88:2036-2042 GLOSSARY BMI 5 body mass index; CCA 5 common carotid artery; CI 5 confidence interval; cIMT 5 carotid intima media thickness; DBP 5 diastolic blood pressure; DD 5 diastolic diameter; FLAIR 5 fluid-attenuated inversion recovery; HDL 5 high-density lipoprotein; ICA 5 internal carotid artery; ICV 5 intracranial volume; IMT 5 intima media thickness; LDL 5 low-density lipoprotein; NOMAS 5 Northern Manhattan Study; OR 5 odds ratio; PWV 5 pulse wave velocity; SBI 5 silent brain infarction; SBP 5 systolic blood pressure; WMH 5 white matter hyperintensity; WMHV 5 white matter hyperintensity volume.

show abstract

Section: Resultssupporting

confidence: 85%

Relationship between carotid arterial properties and cerebral white matter hyperintensities

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Although the associations among carotid WSS, cognitive impairment, and WMLs have been assessed in recent years [ 12 , 21 – 24 ], the results of a few cross-sectional studies are still vague. Okada and colleagues [ 23 ] indicated that peak and end diastolic carotid WSS were significantly associated with the presence of DWMH grade >3 in individuals without apparent cardiovascular diseases. Mutsaerts and coworkers reported that diastolic hemodynamics is a more important contributor to WMLs than mean or systolic hemodynamics [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Low carotid wall shear stress independently accelerates the progression of cognitive impairment and white matter lesions in the elderly

et al. 2017

View full text Add to dashboard Cite

The association of hemodynamics with cognitive impairment and white matter lesions (WMLs) has come to the foreground in recent years. Six hundred eighty-nine elderly participants aged ≥60 years were eligible enrolled. After an average of 5.4 years follow-up, there was a significant decline in Mini-Mental State Examination (MMSE) scores and increases in total white matter hyperintensities (WMH), periventricular (P)WMH, and deep (D)WMH (P < 0.001). The participants were grouped by the tertiles of carotid mean wall shear stress (WSS). The decline in MMSE scores and the increases in total WMH, PWMH, and DWMH decreased from the lowest group to the highest group. There were significant differences between each group comparison (all P <0.05). Mean WSS was an independent and significant factor for the changes in MMSE scores, total WMH, PWMH, and DWMH after adjustment for confounders (P <0.001). The risk of developing cognitive impairment was higher in the lowest (hazard ratio: 2.753; 95% CI: 1.945 to 3.895; P < 0.001) and intermediate (hazard ratio: 1.531; 95% CI: 1.084 to 2.162; P = 0.015) groups than in the highest group after adjustment for confounders. Similar associations were yielded between peak WSS and the changes in MMSE scores, total WMH, PWMH, and DWMH. Our results indicated that carotid WSS is an independent factor for the progression of cognitive impairment and WMLs in the elderly. Low WSS significantly deteriorates the progression of cognitive impairment and WMLs.

show abstract

“…Subjects were participants of a medical check‐up program at Ehime University Hospital Anti‐aging Center, which is specifically designed to evaluate atherosclerosis and cognitive impairment . All clinical data were obtained from the check‐up process.…”

Section: Methodsmentioning

confidence: 99%

Cross‐sectional study of equol producer status and cognitive impairment in older adults

Igase

Igase²,

Tabara

et al. 2017

Geriatrics Gerontology Int

Self Cite

View full text Add to dashboard Cite

show abstract

Mechanical Stresses, Arterial Stiffness, and Brain Small Vessel Diseases

Cited by 17 publications

References 37 publications

Relationship between carotid arterial properties and cerebral white matter hyperintensities

Relationship between carotid arterial properties and cerebral white matter hyperintensities

Low carotid wall shear stress independently accelerates the progression of cognitive impairment and white matter lesions in the elderly

Cross‐sectional study of equol producer status and cognitive impairment in older adults

Contact Info

Product

Resources

About