Mechanical stretching induces fibroblasts apoptosis through activating Piezo1 and then destroying actin cytoskeleton

Li, Yang; Li, Lü; Li, Bingshu; Liao, Wenxin; Liu, Tingting; Shen, Fu‐Ming; Li, Hong

doi:10.7150/ijms.81666

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…There is consistent evidence that hypertrophic scarring can, at least in part, be explained by evading the apoptosis of fibroblasts [ 123 , 124 ]. While stretch has not shown an apoptotic effect on human dermal fibroblasts [ 112 ], mechanical stress in vaginal wall fibroblasts has been shown to lead to apoptosis by disintegration of the actin cytoskeleton [ 125 ]. Fibroblasts, even in organs such as the skin, are a very heterogenous population, and as such, it is important to note that some of these effects appear to be organ-specific [ 126 ].…”

Section: Maturation Phasementioning

confidence: 99%

Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Rennekampff,

Tenenhaus,

Rennekampff

et al. 2024

Life

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The ability to heal one’s wounds is perhaps one of the most fundamental and critical of physiologic processes. This coordinated and closely regulated sequential biological process involves a variety of migratory and resident cells. The activation, modulation, balance, and control of these functions depend upon soluble mediators that activate cells and modulate their diverse functions. Recent advances have identified mechanotransduction as functionally integral in many different cell types and physiologic processes. The mechanically sensitive ion channel Pieoz1 is expressed on platelets, neutrophils, macrophages, endothelial cells, keratinocytes, and fibroblasts, all of which are principally involved in wound healing. On a cellular level, there have been great advances in our understanding of the functional role of Piezo1 mechanotransduction in cutaneous wounding. The blocking of Piezo1 has recently been shown to reduce scarring in vivo and yet, thus far, a comprehensive understanding of the roles that Piezo1 plays in in vivo wound healing remains lacking. Recognizing the ever-present and critical importance of optimal and reparative wound healing, and with the availability of new physical mechanomodulating devices, the time is ripe for gaining deeper insights into optimizing wound healing. In this review, we describe the current knowledge of Piezo1 related to wound healing.

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