Mechanische hämolytische Anämie nach Implantation künstlicher Aortenklappen

Chronic haemolysis occurring in patients following cardiac surgery.

“…There have been a number of reports of patients who have developed overt hemolysis following open-heart surgery (Andersen et al, 1965;Brodeur et al, 1965;DeCesare, Rath, and Hufnagel, 1965;Gehrmann and Loogen, 1964;Kezdi, Head, and Buck, 1964;Pirofsky et al, 1965;Reed and Dunn, 1964;Sayed et al, 1961;Sears and Crosby, 1965;Sigler et al, 1963;Stewart and Sturridge, 1959;Verdon, Forrester, and Crosby, 1963;Viner and Frost, 1965). Of 57 patients so far reported, 8 had repairs of defects without insertion of valves and the remainder had one or more valves replaced.…”

Red Cell Survival in Patients with Aortic Valve Disease

“…Our studies have shown that the red cell survival was not affected by the turbulence of aortic regurgitation nor by the fast turbulent flow of blood through the rough disorganized valves in calcific aortic stenosis. Mechanical haemolytic anaemia after aortic valve replacement has recently been described (Gehrmann and Loogen, 1964;Marsh, 1964;Reed and Dunn, 1964;Stevenson and Baker, 1964). The mechanism of this condition is not known.…”

“…This is supported by the fact that all the reported cases of haemolytic anaemia after aortic valve replacement had residual aortic regurgitation. The two patients described by Gehrmann and Loogen (1964) developed severe haemolytic anaemia and jaundice which coincided with the sudden onset of aortic regurgitation a few months after aortic valve replacement using a Hufnagel tricuspid dacron prosthesis. The cases of haemolytic anaemia following the insertion of a Starr-Edwards aortic prosthesis, reported by Marsh (1964) and Stevenson and Baker (1964), had signs of residual aortic regurgitation.…”

“…The increased destruction of red cells after some corrective cardiac procedures has been recognized (Neill, Farman, Sigler, and Bahnsen, 1961;Sayed, Dacie, Handley, Lewis, and Cleland, 1961;Verdon, Forrester, and Crosby, 1963;Gehrmann and Loogen, 1964;Marsh, 1964;Reed and Dunn, 1964;Stevenson and Baker, 1964). Despite increased haemolysis, anaemia is not always present, since a normal bone marrow is capable of increasing red cell production six or seven times in response to a sustained demand.…”

Chronic haemolysis following insertion of ball valve prostheses.

“…Intravascular haemolysis after the insertion of intracardiac prosthetic material has been reported by Sayed et al (1961), Verdon, Forrester, andCrosby (1963), Sigler et al (1963), Gehrmann and Loogen (1964), Reed and Dunn (1964), Marsh (1964), and Yacoub, Rogers, and Taylor (1965). The haemolysis may be sufficient to produce clinical haemolytic anaemia or may cause a compensated haemolytic state (Yacoub et al, 1965).…”