Mechanism for Possible Chemopreventive Effects of Natural Dietary Compounds on Smoking-induced Tumorigenesis

Regulation of tumor progression via the Snail‐RKIP signaling pathway by nicotine exposure in head and neck squamous cell carcinoma

“…Cigarette smoking is one of the leading causes of a variety of smoke‐associated malignancies, such as lung, gastric, pancreatic, bladder, and head and neck cancers . Accumulating data show that cigarette smoke generates more than 5000 different chemical compounds, among which more than 60 are carcinogenic.…”

“…3 Cigarette smoking is one of the leading causes of a variety of smoke-associated malignancies, such as lung, gastric, pancreatic, bladder, and head and neck cancers. [4][5][6][7] Accumulating data show that cigarette smoke generates more than 5000 different chemical compounds, among which more than 60 are carcinogenic. The tobacco-related carcinogen nitrosamine 4-(methylnitrosamino)21-(3pyridyl)21-butanone (NNK), which is derived from nicotine, is a major component of cigarette smoke and has been identified as the most potent carcinogen.…”

Naturally occurring compounds acting as potent anti‐metastatic agents and their suppressing effects on Hedgehog and WNT/β‐catenin signalling pathways

“…Epidemiological investigations have demonstrated that consumption of tea is together with significant decrease in prevalence of cancer, related to the presence of polyphenolic compounds in tea. 76 Catechins presented in green tea are one of the most important currently characterized flavonoids in recent years. About 30-40% dry weight of a cup of brewed green tea consists of catechins including Epigallo catechin 3-gallate (EGCG) and Epigallocatechin (EGC).…”

“…Epidemiological investigations have demonstrated that consumption of tea is together with significant decrease in prevalence of cancer, related to the presence of polyphenolic compounds in tea . Catechins presented in green tea are one of the most important currently characterized flavonoids in recent years.…”

Molecular Mechanisms of Nicotine-induced Bladder Cancer

“…In addition, it is also suggested that other natural dietary compounds that act through modulating cigarette smoking-induced signaling pathways such as a9-nAChR in breast cancer, 68,69 can provide a further potential application for cancer chemopreventive action in cigarette smoke-related cancers. 70,71 …”