Mechanism of 5-HT contraction in isolated bovine ventricular coronary arteries. Evidence for transient receptor-operated calcium influx channels.

Ratz, Paul H.; Flaim, Stephen F.

doi:10.1161/01.res.54.2.135

Cited by 30 publications

(15 citation statements)

References 36 publications

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“…2, the isolated pig and cattle coronary arteries were contracted by histamine. These results were similar to previous reports in pigs (12,13) and cattle (3,14). In pig coronary arteries, removal of the endothelium increased the maximal response and pD2 value of the histamine-induced contraction ( Fig.…”

Section: Discussionsupporting

confidence: 92%

“…Histamine has been reported to contract pig and cattle coronary arteries in vitro (3,4,12,13), but there are few data about the subtypes of histamine receptors and whether vascular responses to histamine are endothelium-dependent or not in these species (12,13). As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3)(4)(5)(6).…”

mentioning

confidence: 99%

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Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

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ABSTRACT-Vasomotor effects of histamine were examined in isolated coronary arteries from pigs and cattle. Histamine produced a concentration-dependent contraction in these arteries. These contractile responses were dose-dependently inhibited by diphenhydramine. The slopes of the Schild plots, however, were significantly lower than unity in both species. Cimetidine potentiated the histamine-induced contractions at relatively high doses of histamine (larger than 10-5 M) in pig coronary arteries, but did not show a significant effect in cattle arteries. After the removal of endothelium, the Schild plot of diphenhydramine against histamine gave a straight line with a pA2 value of 7.80 and slope of 1.00 in pigs, confirming the competitive nature of the antagonism. In cattle, the slope was significantly lower than unity; however, in the presence of cimetidine, it was not significantly different from unity. Dimaprit did not contract the cattle coronary arteries with endothelium, but contracted them after the removal of endothelium. These results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the Hi-receptors in the smooth muscle cells, and that H1-and H2-receptors in the endothelial cells of pigs and H2-receptors in the smooth muscle cells of cattle modify the histamine-induced vasoconstrictions. Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

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“…23 In experiments on tension development of coronary strips, the significant relaxation to norepinephrine (NE) and epinephrine (EP) has been observed in sheep, 4 rabbit, 5 kitten, 6 bovine, 78 and porcine 79 coronary arteries. In contrast with the weak contraction induced by NE, a relatively strong contraction of porcine or bovine coronary artery can be induced by histamine, 10 serotonin, 8 acetylcholine, 9 or excess KC1. 8 -9 Furthermore, it has been reported that canine coronary artery is much more sensitive to organic calcium an- modifications.…”

mentioning

confidence: 86%

Characteristics of adrenoceptors and [3H]nitrendipine receptors of porcine vascular smooth muscle: differences between coronary artery and aorta.

Nishimura¹,

Kobayashi²,

Nakamura³

1987

Circulation Research

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“…All studies were conducted on tissue taken from male New Zealand White rabbits (2.2-2.4 kg), using previously described methods (3,4 Isometric Tension. To record isometric tension, we placed each 3 mm long vascular ring across two stainless steel wires in a chamber containing 20 ml of fresh oxygenated PS solution at 370C.…”

Section: Methodsmentioning

confidence: 99%

Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.

Flaim¹,

Brannan²,

Swigart³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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This study was designed to determine whether neuroleptic drugs have calcium channel blocking activity in isolated rings of rabbit thoracic aorta. The results confirm previous findings that pimozide and penfluridol are calcium channel blockers. However, the data do not support the conclusion that these agents are selective for the voltage-sensitive calcium channel. The results also show that both haloperidol and chlorpromazine (which represent different classes of neuroleptic drugs) are also calcium channel blockers in vascular smooth muscle.It has been suggested (1) that neuroleptic drugs of the diphenylbutylpiperidine class (pimozide and penfluridol), which differ from other neuroleptics (phenothiazines and butyrophenones) in their ability to relieve both negative and positive symptoms of schizophrenia, owe their activity to an ability to antagonize voltage-dependent calcium channel activity in the brain. These neuroleptic drugs selectively inhibit the binding of [3H]nitrendipine to a rat cerebral cortical membrane fraction and also competitively antagonize potassium-induced calcium-dependent contractions in rat vas deferens. Inhibition of calcium-dependent contractile activity in smooth muscle can be attributed to effects on calcium-dependent mechanisms within the cell that are independent of calcium influx across the cell membrane (2).To test directly the hypothesis that drugs of the diphenylbutylpiperidine class are calcium influx blockers, we measured their effects on the rates of calcium influx in isolated rings of rabbit thoracic aorta (i) under control conditions, (it) during activation of a receptor-operated calcium channel (ROC) by norepinephrine (NE), and (iii) during activation of the potential-dependent calcium channel (PDC) by potassium chloride. Effects on isometric contractile force also were determined. Pimozide and penfluridol (diphenylbutylpiperidines) were compared to chlorpromazine (a phenothiazine), haloperidol (a butyrophenone), prazosin (an a, adrenergic ROC blocker), nifedipine (a PDC blocker), and lanthanum chloride (a nonselective calcium channel blocker). METHODSAll studies were conducted on tissue taken from male New Zealand White rabbits (2.2-2.4 kg), using previously described methods (3, 4).NE [(-)-arterenol bitartrate; Sigma] was dissolved in 20 ,ul of H20 and used in physiological salt (PS) solution (140 mM NaCl/5.9 mM KCl/1 mM MgCl2/10 mM D-glucose/5 mM Hepes/1.5 mM CaCl2, pH 7.3) containing 1.1 puM ascorbic acid (Hoffmann-LaRoche) to inhibit norepinephrine oxidation (ascorbic acid was added to the stock PS solution before pH adjustment). KCI (Fisher) was dissolved in 400 t.l of Isometric Tension. To record isometric tension, we placed each 3 mm long vascular ring across two stainless steel wires in a chamber containing 20 ml of fresh oxygenated PS solution at 370C. The lower wire was secured firmly to an oxygenator, while the upper wire was connected to a tension transducer. Each vascular ring was adjusted to maintain resting (base-line) tension of 1 g during a 60-min ...

show abstract

Mechanism of 5-HT contraction in isolated bovine ventricular coronary arteries. Evidence for transient receptor-operated calcium influx channels.

Cited by 30 publications

References 36 publications

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Characteristics of adrenoceptors and [3H]nitrendipine receptors of porcine vascular smooth muscle: differences between coronary artery and aorta.

Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.

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