Mechanism of Action of a New Prostaglandin Antihypertensive, Viprostol [CL 115 347; (dl)-15-Deoxy-16-Hydroxy-16(??/??)-Vinyl Prostaglandin E2 Methyl Ester]: (II) Effects on the Adrenergic Nervous System

Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.

show abstract

Transdermal Absorption and Skin Metabolism of Viprostol, A Synthetic Prostaglandin E₂Analogue

Nicolau¹,

Yacobi²

1989

Drug Metabolism Reviews

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Mechanism of Action of a New Prostaglandin Antihypertensive, Viprostol [CL 115 347; (dl)-15-Deoxy-16-Hydroxy-16(??/??)-Vinyl Prostaglandin E2 Methyl Ester]: (II) Effects on the Adrenergic Nervous System

Cited by 3 publications

References 0 publications

The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Transdermal Absorption and Skin Metabolism of Viprostol, A Synthetic Prostaglandin E₂Analogue

Contact Info

Product

Resources

About

Mechanism of Action of a New Prostaglandin Antihypertensive, Viprostol [CL 115 347; (dl)-15-Deoxy-16-Hydroxy-16(??/??)-Vinyl Prostaglandin E2 Methyl Ester]: (II) Effects on the Adrenergic Nervous System

Cited by 3 publications

References 0 publications

The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Transdermal Absorption and Skin Metabolism of Viprostol, A Synthetic Prostaglandin E2Analogue

Contact Info

Product

Resources

About

Transdermal Absorption and Skin Metabolism of Viprostol, A Synthetic Prostaglandin E₂Analogue