Mechanism of Action of the Antimicrobial Peptide Caerin1.1

Houri, Aamd; Mechler, Ádám

doi:10.1002/slct.202000851

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…[ 201 ] Besides the membrane disruption mechanism, penetration into the cytoplasm of bacteria to target intracellular compounds has been proposed for AMPs. [ 192,202 ] Some AMPs can directly target the DNA or RNA of bacteria after penetrating the bacterial cytoplasm, although it is obvious that cell‐membrane targeting and permeabilization should occur first. [ 166 ] Lateral phase segregation has been observed from bacterial cell membranes.…”

Section: Sams Inspired By Biomimicrymentioning

confidence: 99%

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Liu

Mehrjou

et al. 2023

Advanced Materials

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The discovery of antibiotics has saved millions of lives, but the emergence of antibiotic‐resistant bacteria has become another problem in modern medicine. To avoid or reduce the overuse of antibiotics in antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better and smarter than conventional therapies. The common goal of smart antibacterial materials (SAMs) is to increase the antibiotic efficacy or function via an antibacterial mechanism different from that of antibiotics in order to increase the antibacterial and biological properties while reducing the risk of drug resistance. The research and development of SAMs are increasingly interdisciplinary because new designs require the knowledge of different fields and input/collaboration from scientists in different fields. A good understanding of energy conversion in materials, physiological characteristics in cells and bacteria, and bactericidal structures and components in nature are expected to promote the development of SAMs. In this review, the importance of multidisciplinary insights for SAMs is emphasized, and the latest advances in SAMs are categorized and discussed according to the pertinent disciplines including materials science, physiology, and biomimicry.This article is protected by copyright. All rights reserved

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Section: Sams Inspired By Biomimicrymentioning

confidence: 99%

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Liu

Mehrjou

et al. 2023

Advanced Materials

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“…Furthermore, all 24 cryptides 3D structures were validated by having more than 90% Ramachandran score. The secondary structure of an antimicrobial peptide is closely related to its function, e.g., binding to bacterial cell wall membranes (Mahlapuu et al, 2016) and binding to intracellular receptors (Houri & Mechler, 2020).…”

Section: -Dimensional (3-d) Structure Prediction and Optimization Of ...mentioning

confidence: 99%

Collagen-Derived Cryptides: Machine-Learning Prediction and Molecular Dynamic Interaction Against Klebsiella pneumoniae Biofilm Synthesis Precursor

Al-Khdhairawi

Mhd-Marzuki

Tan

et al. 2022

MAB

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Collagen-derived cryptic peptides (cryptides) are biologically active peptides derived from the proteolytic digestion of collagen protein. These cryptides possess a multitude of activities, including antihypertensive, antiproliferative, and antibacterial. The latter, however, has not been extensively studied. The cryptides are mainly obtained from the protein hydrolysate, followed by characterizations to elucidate the function, limiting the number of cryptides investigated within a short period. The recent threat of antimicrobial resistance microorganisms (AMR) to global health requires the rapid development of new therapeutic drugs. The current study aims to predict antimicrobial peptides (AMP) from collagen-derived cryptides, followed by elucidating their potential to inhibit biofilm-related precursors in Klebsiella pneumoniae using in silico approach. Therefore, cryptides derived from collagen amino acid sequences of various types and species were subjected to online machine-learning platforms (i.e., CAMPr3, DBAASP, dPABBs, Hemopred, and ToxinPred). The peptide-protein interaction was elucidated using molecular docking, molecular dynamics, and MM-PBSA analysis against MrkH, a K. pneumoniae’s transcriptional regulator of type 3 fimbriae that promote biofilm formation. As a result, six potential antibiofilm inhibitory cryptides were screened and docked against MrkH. All six peptides bind stronger than the MrkH ligand (c-di-GMP; C2E).

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Gold Nanoparticles and Antimicrobial Peptides: A Novel Combination

Balcı,

Ergüden

2024

ChemistrySelect

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This article examines the diverse conjugation forms of AMP‐AuNP nanostructures that arise from the amalgamation of antimicrobial peptides (AMPs) and gold nanoparticles (AuNPs), as well as their prospective utility in the field of biomedicine. AMPs are a class of naturally occurring microbicidal compounds that are recognized for their wide range of inhibitory effects and distinctive modes of operation. The utilization of AuNPs in diverse biomedical applications is facilitated through the application of nanotechnology. AMP‐AuNP nanostructures exhibit diverse features through the utilization of molecular linkage techniques. The aforementioned qualities encompass the ability to expedite the process of wound healing, facilitate precise targeting through the incorporation of DNA aptamers, serve as a means for bacterial imaging, enable the use of photothermal therapy, and contribute to the advancement of prospective treatments for fungal infections. The utilization of these synthesized antimicrobial gold nanostructures in many biomedical applications holds significant promise for advancing treatments and enhancing disease management.

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Mechanism of Action of the Antimicrobial Peptide Caerin1.1

Cited by 4 publications

References 43 publications

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Collagen-Derived Cryptides: Machine-Learning Prediction and Molecular Dynamic Interaction Against Klebsiella pneumoniae Biofilm Synthesis Precursor

Gold Nanoparticles and Antimicrobial Peptides: A Novel Combination

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