Mechanism of allopurinol-mediated increase in enzyme activity in man

Platelet monoamine oxidase activity during the course of a schizophreniform psychosis

“…The previous history of gout is also of some interest, although it is not generally believed to have an association with schizophrenia. Allopurinol has been reported to mediate the increase of orotate phosphoribosyltransferase (OPRT), and orotidylic decarboxylase (ODC) (Beardmore et al, 1972) but its effects on MAO activity are unknown.…”

PURINES, PYRIMIDINES & RELATED COMPOUNDS

“…Increases in the excretion of pseudouridine, uracil, xanthine, and orotidine excretion have been noted (65) but there was no apparent relationship to the hyperuricemia. The excretion of uric acid may be within the normal range, under 590 mg./day on a purine free diet, or greatly increased.…”

“…These compounds occur in tea, coffee and chocolate, and following an intake of 200 mg./day of each of these compounds about 10 to 20 per cent were recovered as the appropriate methylxanthines. (65) (12) Dietary control is therefore very important in any study of the urinary excretion of U.V.…”

Analytical derivatization–a tool for determination of orotic acid

“…In most cases, orotic aciduria arises from inherited defects of enzymes involved in the urea cycle after synthesis of intramitochondrial carbamoyl phosphate [1]. Moreover, the high level of urinary orotate occurs also in purine nucleoside phosphorylase deficiency [2], lysinuric protein intolerance [3] and could be induced by drugs such as allopurinol [4,5] and 6-azauridine [6]. Taken together abnormal values of OA are found in 11 diseases making its measurement one of the most important tools to diagnose some metabolic defects.…”