Mechanism of angiogenesis promotion with Shexiang Baoxin Pills by regulating function and signaling pathway of endothelial cells through macrophages

Zhang, Jiange; Cui, Qianfei; Zhao, Yingna; Guo, Runan; Chen, Zhan; Jiang, Peng; Luan, Pengwei; Zhang, Pei; Wang, Feiyun; Yang, Liuqing; Yang, Xianchao; Xu, Yulan

doi:10.1016/j.atherosclerosis.2019.11.005

Cited by 31 publications

(19 citation statements)

References 25 publications

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“…It was found that Shexiang Baoxin pills could reduce the left ventricular volume, increase the left ventricular inner diameter, and improve the heart function by increasing cardiac output and enhancing cardiac systolic function. It was in line with the research results of Tian et al and Zhang et al [13,21]. Finally, the difference between the total effective rates of and echocardiogram in two groups was evaluated.…”

Section: Discussionsupporting

confidence: 83%

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Gao

Wang

et al. 2021

Journal of Healthcare Engineering

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This paper was aimed to explore the application of the block matching pyramid (BMP) algorithm in echocardiographic spot tracking in patients with coronary heart disease (CHD) and angina pectoris, as well as the effect of Shexiang Baoxin pills (a kind of drug containing musk, which is good for cardiac diseases) on blood lipids, cardiac function, and curative effect. 206 patients with CHD angina pectoris in the hospital from July 2018 to May 2020 were selected as the research subjects and were enrolled into the control (Ctrl) group (conventional treatment, n = 103) and the observation group (the Shexiang Baoxin pill was given on the basis of conventional treatment, n = 103) in random. Then, the patients’ echocardiograms were obtained, and the BMP algorithm was used to track the echocardiograms. At 12 months after treatment, the total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were compared. Besides, the differences between left ventricular end-systolic volume (LVESV), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic dimension (LVEDD), cardiac index (CI), cardiac output (CO), and LVEF were observed. Finally, the efficacy of angina pectoris and electrocardiogram was calculated. It was found that the BMP algorithm can track the echocardiograms and display the movement and displacement of the patients’ left ventricle. After treatment, in contrast with the Ctrl, the levels of TC, TG, and LDL-C in the observation group were obviously lower ( P < 0.05 ); the LVESV, LVEDV, and LVEF were obviously lower ( P < 0.05 ), the LVESD, LVEDD, CO, and CI were obviously higher ( P < 0.05 ), the total score of angina after treatment was obviously lower ( P < 0.05 ), and the total effective rates of angina pectoris and echocardiogram were obviously higher ( P < 0.05 ). In conclusion, echocardiographic spot tracking can realize the diagnosis of patients with CHD angina pectoris, and Shexiang Baoxin pill can regulate the blood lipid level and improve the echocardiographic indicators and the clinical efficacy is obvious.

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Section: Discussionsupporting

confidence: 83%

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Gao

Wang

et al. 2021

Journal of Healthcare Engineering

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“…Protein concentrations were determined with the Enhanced BCA Protein Kit (Beyotime Biotechnology). Western blots were performed as described 34 using antibodies (Santa Cruz Biotechnology) against VEGF-A (sc-152), MMP9 (sc-6840), HuR (sc-5261), and β -actin (sc-8432). Detections were analyzed with Azure Biosystem (Azure c600, Azure Biosystem™, Dublin, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

Zhu

Yang

et al. 2020

Acta Pharmaceutica Sinica B

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HuR (human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescence polarization (FP) based high-throughput screening (HTS) system, the clinically used drug eltrombopag was identified. Activity of eltrombopag on molecular level was verified with FP, electrophoretic mobility shift assay (EMSA), simulation docking and surface plasmon resonance (SPR). Further, we showed that eltrombopag inhibited in vitro cell proliferation of multiple cancer cell lines and macrophages, and the in vivo anti-tumor activity was also demonstrated in a 4T1 tumor-bearing mouse model. The in vivo data showed that eltrombopag was efficient in reducing microvessels in tumor tissues. We then confirmed the HuR-dependent anti-angiogenesis effect of eltrombopag in 4T1 cells and RAW264.7 macrophages with qRT-PCR, HuR-overexpression and HuR-silencing assays, RNA stability assays, RNA immunoprecipitation and luciferase assays. Finally, we analyzed the in vitro anti-angiogenesis effect of eltrombopag on human umbilical vein endothelial cells (HUVECs) mediated by macrophages with cell scratch assay and in vitro Matrigel angiogenesis assay. With these data, we revealed the HuR-dependent anti-angiogenesis effect of eltrombopag in breast tumor, suggesting that the existing drug eltrombopag may be used as an anti-cancer drug.

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“…CD4 + T cells (consisting of Th1, Th2, Th17, and Tregs), which are responsible for inflammatory response, boost arteriogenesis in a murine model of hindlimb ischemia (Nossent et al, 2017). Moreover, CD4 + T cells play essential roles in activating and polarizing macrophages, which have been demonstrated to have the ability to promote angiogenesis (Zhang et al, 2020). Th17 promotes angiogenesis and increases cerebral blood flow in the ischemic penumbra, partly owing to its potent effect in promoting the migration and sprouting of ECs (Kwee et al, 2018).…”

Section: Cd4 + T Cellsmentioning

confidence: 99%

Inflammation-Mediated Angiogenesis in Ischemic Stroke

Zhu

Zhang

Zhong

et al. 2021

Front. Cell. Neurosci.

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Stroke is the leading cause of disability and mortality in the world, but the pathogenesis of ischemic stroke (IS) is not completely clear and treatments are limited. Mounting evidence indicate that neovascularization is a critical defensive reaction to hypoxia that modulates the process of long-term neurologic recovery after IS. Angiogenesis is a complex process in which the original endothelial cells in blood vessels are differentiated, proliferated, migrated, and finally remolded into new blood vessels. Many immune cells and cytokines, as well as growth factors, are directly or indirectly involved in the regulation of angiogenesis. Inflammatory cells can affect endothelial cell proliferation, migration, and activation by secreting a variety of cytokines via various inflammation-relative signaling pathways and thus participate in the process of angiogenesis. However, the mechanism of inflammation-mediated angiogenesis has not been fully elucidated. Hence, this review aimed to discuss the mechanism of inflammation-mediated angiogenesis in IS and to provide new ideas for clinical treatment of IS.

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Mechanism of angiogenesis promotion with Shexiang Baoxin Pills by regulating function and signaling pathway of endothelial cells through macrophages

Cited by 31 publications

References 25 publications

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

Inflammation-Mediated Angiogenesis in Ischemic Stroke

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