Mechanism of antioxidant properties of quercetin and quercetin-DNA complex

Song, Xiaoli; Wang, Yali; Gao, Liguo

doi:10.1007/s00894-020-04356-x

Cited by 76 publications

(49 citation statements)

References 44 publications

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“…In addition, the cyclic guanosine monophosphate (cGMP) /nitrate formation in the platelets activated by lycopene also constrains platelet aggregation [143]. Quercetin is a potential chelator of metal ions, constraining xanthine oxidase while reducing lipid peroxidation and scavenging free radicals, which ultimately help to reduce the risk of CVD [144,145]. Furthermore, it reduces the levels of oxidized LDL in the plasma, since LDL oxidation is stimulated by macrophages or myeloperoxidase, inhibits the generation of hyperoxide and reduces systolic blood pressure in obese patients [146][147][148].…”

Section: Tomato In Cvdsmentioning

confidence: 99%

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Ali

Sina

Khandker

et al. 2020

Foods

278

119

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Tomatoes are consumed worldwide as fresh vegetables because of their high contents of essential nutrients and antioxidant-rich phytochemicals. Tomatoes contain minerals, vitamins, proteins, essential amino acids (leucine, threonine, valine, histidine, lysine, arginine), monounsaturated fatty acids (linoleic and linolenic acids), carotenoids (lycopene and β-carotenoids) and phytosterols (β-sitosterol, campesterol and stigmasterol). Lycopene is the main dietary carotenoid in tomato and tomato-based food products and lycopene consumption by humans has been reported to protect against cancer, cardiovascular diseases, cognitive function and osteoporosis. Among the phenolic compounds present in tomato, quercetin, kaempferol, naringenin, caffeic acid and lutein are the most common. Many of these compounds have antioxidant activities and are effective in protecting the human body against various oxidative stress-related diseases. Dietary tomatoes increase the body’s level of antioxidants, trapping reactive oxygen species and reducing oxidative damage to important biomolecules such as membrane lipids, enzymatic proteins and DNA, thereby ameliorating oxidative stress. We reviewed the nutritional and phytochemical compositions of tomatoes. In addition, the impacts of the constituents on human health, particularly in ameliorating some degenerative diseases, are also discussed.

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Section: Tomato In Cvdsmentioning

confidence: 99%

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Ali

Sina

Khandker

et al. 2020

Foods

278

119

View full text Add to dashboard Cite

show abstract

“…To obtain a deeper insight into the antiradical properties, the thermodynamics of these processes for C 10 (DAPANO) 2 and C 10 PDA was evaluated using the DFT approach (B3LYP, B2PLYP, and M06-2X) and the ab initio coupled cluster-type method [DLPNO-CCSD(T)]). The DLPNO-CCSD(T) method has been reported to reproduce results of the “golden standard” canonical CCSD(T) while remaining computationally feasible for real chemical systems [ 32 , 33 , 34 , 35 , 36 , 37 ]. Moreover, the excellent performance of the DLPNO-CCSD(T) method has been confirmed for the determination of the energetics of the hydrogen atom transfer reaction [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Antiradical Properties of N-Oxide Surfactants—Two in One

Lewińska

Kulbacka

Domżał-Kędzia

et al. 2021

IJMS

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Surfactants are molecules that lower surface or interfacial tension, and thus they are broadly used as detergents, wetting agents, emulsifiers, foaming agents, or dispersants. However, for modern applications, substances that can perform more than one function are desired. In this study we evaluated antioxidant properties of two homological series of N-oxide surfactants: monocephalic 3-(alkanoylamino)propyldimethylamine-N-oxides and dicephalic N,N-bis[3 ,3′-(dimethylamino)propyl]alkylamide di-N-oxides. Their antiradical properties were tested against stable radicals using electron paramagnetic resonance (EPR) and UV-vis spectroscopy. The experimental investigation was supported by theoretical density functional theory (DFT) and ab initio modeling of the X–H bonds dissociation enthalpies, ionization potentials, and Gibbs free energies for radical scavenging reactions. The evaluation was supplemented with a study of biological activity. We found that the mono- and di-N-oxides are capable of scavenging reactive radicals; however, the dicephalic surfactants are more efficient than their linear analogues.

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“…Recently it was found that quercetin can also directly interact with DNA. Thus, it has been reported that quercetin may protect against oxidationinduced DNA damage [58]. In addition, quercetin is capable of modification of epigenetic regulations by inhibiting DNA methylation and by influencing histone acetylation [59].…”

Section: Discussionmentioning

confidence: 99%

Topical onion juice mitigates the morphological alterations of the cornea in the aged male rats

2021

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Aging is associated with structural and functional changes of the cornea. Fresh onion juice contains phenolic compounds and flavonoids that may provide an anti-aging effect. The aim of this study was to assess the ability of the onion juice to ameliorate these aging changes. Rats were grouped as adult and aged groups. Rats of both groups received eye drops of diluted onion juice in their right eyes every 8 hours for 12 weeks, while the left ones were served as control eyes. The corneas of both eyes underwent histopathological, immunohistochemical and morphometric assessments, in addition to measuring their intraocular pressure (IOP). The aged group exhibited a significantly elevated IOP, decreased tear secretion, degenerated corneal epithelium and endothelium, surface erosions and stromal edema with irregular collagen fibers. Administration of onion juice led to lowering of IOP, significant increase in tearing, restoration of most of epithelial, endothelial and stromal integrity, and increased epithelial, keratocystic and endothelial cell densities. Immunohistochemically, the epithelium and endothelium revealed positive immune reactions for both epidermal growth factor receptor (EGFR) and paired box protein-6 (PAX6) in the control and onion-treated corneas of the adult group, while these immune reactions were negative in the untreated aged ones. Onion drops in aged corneas showed a positive immune reaction for EFGR and PAX6 involving the epithelial and endothelial layers. In conclusion, topical onion juice improves corneal aging changes through its direct effect, and indirectly through lowering IOP and enhancing tear secretion.

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Mechanism of antioxidant properties of quercetin and quercetin-DNA complex

Cited by 76 publications

References 44 publications

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Antiradical Properties of N-Oxide Surfactants—Two in One

Topical onion juice mitigates the morphological alterations of the cornea in the aged male rats

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