Mechanism of Cell Interactions with Water-Dispersed Carbon Nanohorns

Murakami, Tatsuya; Nakatani, Masashi; Kokubo, Masahiro; Nakatsuji, Hideaki; Inada, Mami; Imahori, Hiroshi; Yudasaka, Masako; Iijima, Sumio; Tsuchida, Kunihiro

doi:10.1166/nnl.2013.1544

Cited by 4 publications

(2 citation statements)

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“…Secondly, SWNHs are available in large quantities with high purity, free from metal catalysts, which avoids the introduction of toxic impurities during the synthetic process . Thirdly, SWNHs are quite biocompatible, with numerous toxicity evaluations having demonstrated that there is no obvious acute toxicity either in vitro or in vivo . Moreover, SWNHs have large surface areas, such that great numbers of guest molecules may be adsorbed to construct nanoplatforms with huge loading capacity .…”

Section: Introductionmentioning

confidence: 99%

Near‐Infrared Light Responsive Imaging‐Guided Photothermal and Photodynamic Synergistic Therapy Nanoplatform Based on Carbon Nanohorns for Efficient Cancer Treatment

Gao

Dong

Lin

et al. 2018

Chemistry A European J

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Indocyanine green (ICG) is an effective light absorber for laser-mediated photodynamic therapy. However, applications of ICG are limited due to its rapid degradation and poor photostability in water. Herein, we report the development of a multifunctional nanoplatform by coating ICG on the surface of single-walled carbon nanohorns (SWNHs) through π-π stacking, obtaining SWNH-ICGs with high solubility and stability under physiological conditions. The SWNH-ICGs could be used as a single nanoplatform to simultaneously produce satisfactory hyperthermia and reactive oxygen species under near-infrared (NIR) laser irradiation. In addition, the SWNH-ICGs not only improved the photostability of ICG in different media, but also protected it from light degradation. The SWNH-ICGs exhibited highly efficient thermal/photoacoustic (PA) imaging-guided photothermal therapy (PTT) and photodynamic therapy (PDT) effects, even under low-power laser irradiation (0.3 W cm ) in vitro. Combined PTT and PDT effectively killed triple-negative breast cancer 4T1 cells, demonstrating a markedly improved and synergistic therapeutic effect compared to PTT or PDT alone. Furthermore, significant tumor growth inhibition as well as tumor cell death were observed following PTT/PDT at 808 nm laser irradiation, confirming the synergistic effects of SWNH-ICGs over free ICG in vivo. This facile and simple methodology for thermal/PA imaging-guided PTT/PDT suggests that SWNH-ICGs may serve as an effective nanoplatform for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Near‐Infrared Light Responsive Imaging‐Guided Photothermal and Photodynamic Synergistic Therapy Nanoplatform Based on Carbon Nanohorns for Efficient Cancer Treatment

Gao

Dong

Lin

et al. 2018

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…Secondly, SWNHs are available in large quantities with high purity and free of metal catalysis, which avoids the introduction of toxic impurities during the synthetic process . Thirdly, SWNHs are quite biocompatible and all kinds of toxicity evaluations have suggested there is no obviously acute toxicity both in vitro and in vivo . To the best of our knowledge, the PAI guided PTT platform based on SWNHs has not yet been reported .…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Imaging Guided Near‐Infrared Photothermal Therapy Using Highly Water‐Dispersible Single‐Walled Carbon Nanohorns as Theranostic Agents

Chen

Wang

Nie

et al. 2014

Adv Funct Materials

145

102

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The poly(maleic anhydride‐alt‐1‐octadecene‐poly(ethylene glycol)) (C18PMH‐PEG) modified single‐walled carbon nanohorns (SWNHs) are designed with high stability and biocompatibility. The as‐prepared SWNHs/C18PMH‐PEG not only can serve as an excellent photothermal agent but also can be used as a promising photoacoustic imaging (PAI) agent both in vitro and in vivo due to its strong absorption in the near infrared (NIR) region. The PAI result reveals that the SWNHs/C18PMH‐PEG possesses ultra long blood circulation time and can significantly be accumulated at the tumor site through the enhanced penetration and retention (EPR) effect. The maximum accumulation of SWNHs/C18PMH‐PEG at tumor site could be achieved at the time point of 24 h after intravenous injection, which is considered to be the optimal time for the 808 nm laser treatment. The subsequent photothermal ablation of tumors can be achieved without triggering any side effects. Therefore, a PAI guided PTT platform based on SWNHs is proposed and highlights the potential theranostic application for biomedical uses.

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Carbon Nanomaterials for Photothermal Therapies

Yang

Yan

et al. 2018

Carbon Nanomaterials for Bioimaging, Bioanalysis, and Therapy

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Mechanism of Cell Interactions with Water-Dispersed Carbon Nanohorns

Cited by 4 publications

References 0 publications

Near‐Infrared Light Responsive Imaging‐Guided Photothermal and Photodynamic Synergistic Therapy Nanoplatform Based on Carbon Nanohorns for Efficient Cancer Treatment

Near‐Infrared Light Responsive Imaging‐Guided Photothermal and Photodynamic Synergistic Therapy Nanoplatform Based on Carbon Nanohorns for Efficient Cancer Treatment

Photoacoustic Imaging Guided Near‐Infrared Photothermal Therapy Using Highly Water‐Dispersible Single‐Walled Carbon Nanohorns as Theranostic Agents

Carbon Nanomaterials for Photothermal Therapies

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