2012
DOI: 10.1016/b978-0-12-394305-7.00006-9
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Mechanism of Function of Viral Channel Proteins and Implications for Drug Development

Abstract: Viral channel-forming proteins comprise a class of viral proteins which, similar to their host companions, are made to alter electrochemical or substrate gradients across lipid membranes. These proteins are active during all stages of the cellular life cycle of viruses. An increasing number of proteins are identified as channel proteins, but the precise role in the viral life cycle is yet unknown for the majority of them. This review presents an overview about these proteins with an emphasis on those with avai… Show more

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Cited by 31 publications
(25 citation statements)
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References 314 publications
(414 reference statements)
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“…A growing number of viral genomes are being identified as encoding a specialised type of membrane protein which form oligomeric ion channels [1][2][3][4][5][6]. These viral channel forming proteins (VCPs), also called viroporins, pose an interesting challenge for the understanding of ion channel mechanics in general, due to their low molecular weight.…”
Section: Introductionmentioning
confidence: 99%
“…A growing number of viral genomes are being identified as encoding a specialised type of membrane protein which form oligomeric ion channels [1][2][3][4][5][6]. These viral channel forming proteins (VCPs), also called viroporins, pose an interesting challenge for the understanding of ion channel mechanics in general, due to their low molecular weight.…”
Section: Introductionmentioning
confidence: 99%
“…Many viruses encode integral membrane proteins, which render the lipid membrane permeable for ions and some of them to small molecules . The proteins either exist in a bitopic (e.g., M2 from influenza A, Vpu from HIV‐1, 8a from SARS‐CoV) or polytopic form (e.g., p7 from HCV, 2B from entero viruses, and 3a from SARS‐CoV).…”
Section: Introductionmentioning
confidence: 99%
“…Structural information about Vpu is mainly derived from NMR spectroscopic investigations of protein fragments representing the TMD or the cytoplasmic domain, with the former identified to be helical (reviewed in). A special feature of the TMD is experimentally found to be a kink around a central amino acid Ile‐17 .…”
Section: Introductionmentioning
confidence: 99%
“…Two types of channel proteins can be distinguished, one of which exerts its action in the cell that produces it, and the other which targets a cell other than the one that makes it [Saier, 2000]. The latter proteins are toxins that form pores in the membranes of a target organism, releasing nutrients for the predatory organism while killing the target [Fischer et al, 2012; Saris et al., 2009]. Toxins can similarly exist in small and large forms, where simple peptide toxins usually have no more than 1 or 2 transmembrane segments.…”
Section: Introductionmentioning
confidence: 99%