Mechanism of Hardness of Aged Compacts

Lordi, Nicholas G.; Shiromani, P. K.

doi:10.3109/03639048409040780

Cited by 18 publications

(3 citation statements)

References 2 publications

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“…This resulted in extensive dissolution, which could dissolve interparticulate bonds formed during compaction, resulting in a considerable reduction in tensile strength. 47 The coprocessing step involved the distribution of dissolved Mg(NO 3 ) 2 •6H 2 O or NaCl on a starch powder bed, followed by a drying step to remove the water content. Rapid water removal could cause the dissolved salts to recrystallize into smaller particles.…”

Section: Discussionmentioning

confidence: 99%

“…The decrease in the tensile strength of tablets containing Mg(NO 3 ) 2 ·6H 2 O during post-compaction storage could be attributed to the deliquescence of Mg(NO 3 ) 2 ·6H 2 O. This resulted in extensive dissolution, which could dissolve interparticulate bonds formed during compaction, resulting in a considerable reduction in tensile strength …”

Section: Discussionmentioning

confidence: 99%

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Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Veronica,

Heng,

Liew

2024

Mol. Pharmaceutics

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Excipients are ubiquitous in pharmaceutical products, and often, they can also play a critical role in maintaining product quality. For a product containing a moisture-sensitive drug, moisture can be deleterious to the product stability during storage. Therefore, using excipients that interact with moisture in situ can potentially alleviate product stability issues. In this study, the interactive behavior of starch with moisture was augmented by coprocessing maize starch with sodium chloride (NaCl) or magnesium nitrate hexahydrate [Mg(NO 3 ) 2 •6H 2 O] at different concentrations (5 and 10%, w/w). The effect of the formulation on drug stability was assessed through the degradation of acetylsalicylic acid, which was used as the model drug. The results showed that coprocessing of the starch with either NaCl or Mg(NO 3 ) 2 •6H 2 O impacted the number of water molecule binding sites on the starch and how the sorbed moisture was distributed. The coprocessed excipients also resulted in lower drug degradation and lesser changes in tablet tensile strength during postcompaction storage. However, corresponding tablet formulations containing physical mixtures of starch and salts did not yield promising outcomes. This study demonstrated the advantageous concomitant use of common excipients by coprocessing to synergistically mitigate the adverse effects of moisture and promote product stability when formulating a moisture-sensitive drug. In addition, the findings could help to improve the understanding of moisture−excipient interactions and allow for the judicious choice of excipients when designing formulations containing moisture-sensitive drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Veronica,

Heng,

Liew

2024

Mol. Pharmaceutics

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“…In a fairly dry environment, the water will be tightly bound to a non-freely movable layer of water, which is denoted as monolayer-absorbed moisture (Ahlneck and Alderborn, 1989;Sandell, 1992;Van Campen et al, 1980;Zografi, 1988) Lordi and Shiromani, 1984) (e) Mechanical interlocking; this is the hooking and twisting of powder particles together in a tablet (Brewin, 2007;McCormick 2005).…”

Section: Bonding During Compactionmentioning

confidence: 99%

Powder Compaction: Compression Properties of Cellulose Ethers

Ghori

Conway

2016

British Journal of Pharmacy

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Effective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.

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The effect of interparticulate friction and moisture on the crushing strength of sodium chloride compacts

Down

McMullen

1985

Powder Technology

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Mechanism of Hardness of Aged Compacts

Cited by 18 publications

References 2 publications

Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Powder Compaction: Compression Properties of Cellulose Ethers

The effect of interparticulate friction and moisture on the crushing strength of sodium chloride compacts

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