Mechanism of inhibition of melanogenesis by hydroquinone

Palumbo, Anna; d’Ischia, Marco; Misuraca, Giovanna; Prota, Giuseppe

doi:10.1016/0304-4165(91)90186-k

Cited by 209 publications

(141 citation statements)

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“…The most commonly used is quinol (hydroquinone) (Lerner, 1971;Palumbo et al, 1991). Other compounds which have potential in this area include 4-hydroxy-anisole (Naish and Riley, 1989) and phosphonic acid and phosphinic analogues of tyrosine and DOPA (Lejczak eral., 1990).…”

Section: Phenolic Adsorbentsmentioning

confidence: 99%

Diphenol Oxidases, Enzyme-catalysed Browning and Plant Disease Resistance

Walker

Ferrar

1998

Biotechnology and Genetic Engineering Reviews

159

120

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Section: Phenolic Adsorbentsmentioning

confidence: 99%

Diphenol Oxidases, Enzyme-catalysed Browning and Plant Disease Resistance

Walker

Ferrar

1998

Biotechnology and Genetic Engineering Reviews

159

120

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“…잘 알려진 tyrosinase 억제 물질인 누룩곰팡이로부터 분리된 kojic acid [13], hydroquinone [15], oxyresveratrol [17], 그리고 p-hydroxybenzyl alcohol [14] (Fig. 1, 2 …”

Section: 서 론unclassified

Inhibitory Effects of Fucoidan on Melanin Synthesis and Tyrosinase Activity

2009

Journal of Life Science

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Korea -Melanogenesis is a physiological process that results in the synthesis of melanin pigments.Tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, which can be improved by treatment with depigmenting agents. Among the possible melanin-reducing compounds, tyrosinase inhibitors are most promising for preventing and treating pigmentation disorder and are used as skin-whitening agents in the cosmetic industry. In the present study, the effects of fucoidan on melanogenesis and tyrosinase activity of B16F10 melanoma cells were investigated. Melanin synthesis and tyrosinase activity in B16F10 melanoma cells were decreased in a dose-dependent manner by fucoidan. Melanin production and tyrosinase activity in B16F10 melanoma cells stimulated by α-melanocyte stimulating hormone (α-MSH) were inhibited by fucoidan with a dose-dependent manner compared to control. Fucoidan inhibited tyrosinase activity of B16F10 melanoma cells with a dose-dependent manner as assessed by 3,4-dihydroxyphenylalanine (DOPA) staining. In conclusion, these findings indicate that fucoidan, which inhibit melanin synthesis and tyrosinase activity, is an effective skin-whitening agent.

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“…Hydroquinone HQ is used as an antioxidant in various industries and is a well-known antimelanogenesis agent employed as a whitening ingredient in cosmetics and pharmaceuticals since the 1960s 1,2 . The maintenance of the inherent biological activity in vivo, in particular, the chemical modification of the hydroxyl groups at carbon 1 or 4 of HQ, is of interest.…”

Section: Introductionmentioning

confidence: 99%