Mechanism of Interferon Alpha on Inhibition of Metastasis and Angiogenesis of Hepatocellular Carcinoma After Curative Resection in Nude Mice

Endogenous Inhibitors of Angiogenesis

“…IFN-a reduces urokinase-type plasminogen activator and plasminogen activator inhibitor-1 activity (135) and significantly inhibits MMP-9 enzymatic activity and protein expression (136). IFN-a and IFN-h treatment also inhibits angiogenesis by down-regulation of bFGF expression (137)(138)(139), but other studies suggest that the action of IFN-a is not mediated by bFGF or VEGF (140)(141)(142).…”

Effects of interferon alpha treatment on recurrence and survival after complete resection or ablation of hepatocellular carcinoma: A meta‐analysis of randomized controlled trials

“…20 Among these, IFN therapy may be one of the most promising approaches because IFNs not only possess antitumor properties including antiproliferative, 21,22 antiangiogenic, [23][24][25] and immunomodulatory effects 26 on tumors, but also have antiviral activities with clearance or suppression of hepatitis B virus (HBV) and hepatitis C virus (HCV) (HBV and HCV infections are the most common etiologies of HCC) in a variable proportion of patients. [27][28][29] In recent years, several clinical trials have suggested that adjuvant IFN-a treatment could obviously influence recurrence and survival of HCC patients after resection or ablation, while results in these trials were inconsistent.…”

Viral hepatitis and hepatocellular carcinoma: etiology and management

“…IFN has antineoplastic properties that are partly mediated through inhibition of angiogenesis and promoting tumor cell apoptosis. In mice models of HCC IFN-alpha decreases serum vascular endothelial growth factor and microvessel density which is associated with a significantly lower rate of lung metastases and recurrent HCC after resection, P<0.05 (68). IFN may inhibit tumorogenesis through anti-angiogenesis by downregulating vascular endothelial growth factor.…”