Mechanism of intracellular detection of glucose through nonenzymatic and boronic acid functionalized carbon dots

Kiran, Shumaila; Misra, R.D.K.

doi:10.1002/jbm.a.35421

Cited by 62 publications

(21 citation statements)

References 62 publications

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“…In vivo bioimaging and biosensing based on functionalized C-dots was investigated by various researchers. 10,14,16,22,23,25,167,168,176,178,188,[198][199][200][201][202][203][204][205][206][207][208][209][210] The first work on C-dots for bioimaging applications was reported by the Sun group. 167 In this paper, the authors synthesized PEG 1500Npassivated C-dots via laser ablation and passivation.…”

Section: Bioapplicationmentioning

confidence: 99%

Improving the functionality of carbon nanodots: doping and surface functionalization

et al. 2016

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Distinct from conventional carbon nanostructures, such as fullerene, graphene, and carbon nanotubes, carbon nanodots (C-dots) exhibit unique properties such as strong fluorescence, high photostability, chemical inertness, low toxicity, and biocompatibility. Various synthetic routes for C-dots have been developed in the last few years, and now intense research efforts have been focused on improving their functionality. In this aspect, doping and surface functionalization are two major ways to control the chemical, optical, and electrical properties of C-dots. Doping introduces atomic impurities into C-dots to modulate their electronic structure, and surface functionalization modifies the C-dot surface with functional molecules or polymers. In this review, we summarize recent progress in doping and surface functionalization of C-dots for improving their functionality, and offer insight into controlling the properties of C-dots for a variety of applications ranging from biomedicine to optoelectronics to energy.

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Section: Bioapplicationmentioning

confidence: 99%

Improving the functionality of carbon nanodots: doping and surface functionalization

et al. 2016

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“…In addition to that, the authors found that the presence of sulfide anions can recover the fluorescence of the quenched CNDs, leading to the development of an "off-on" system. Intracellular glucose was the target of the aminophenyl boronic acid-functionalized CNDs that Kiran et al developed [84]. The higher the concentration of the intracellular glucose the lower the intensity of the fluorescence emitted.…”

Section: Target-specific Imaging Applications For Eukaryotic Cellsmentioning

confidence: 99%

Bioimaging Applications of Carbon Nanodots: A Review

Kasouni

Chatzimitakos

Stalikas

2019

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Carbon nanodots (CNDs) is the newest member of carbon-based nanomaterials and one of the most promising for the development of new, advanced applications. Owing to their unique and unparalleled physicochemical and photoluminescent properties, they are considered to be a rising star among nanomaterials. During the last decade, many applications have been developed based on CNDs. Among others, they have been used as bioimaging agents to label cells and tissues. In this review, we will discuss the advancements in the applications of CNDs in in the field of imaging, in all types of organisms (i.e., prokaryotes, eukaryotes, and animals). Selective imaging of one type of cells over another, imaging of (bio)molecules inside cells and tumor-targeting imaging are some of the studies that will be discussed hereafter. We hope that this review will assist researchers with obtaining a holistic view of the developed applications and hit on new ideas so that more advanced applications can be developed in the near future.

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“…On the other hand, they may cause the mediated signaling cascade. Moreover, nanoparticles may potentially act like enzyme in many biological chemical reactions, named as nanozyme, though whether C‐dots also have the nanozyme‐inhibitor activity is unclear. Herein, we tested the function of C‐dots in peroxidase activity with pH‐mediated regulation and their potential to react with reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

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Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

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Mechanism of intracellular detection of glucose through nonenzymatic and boronic acid functionalized carbon dots

Cited by 62 publications

References 62 publications

Improving the functionality of carbon nanodots: doping and surface functionalization

Improving the functionality of carbon nanodots: doping and surface functionalization

Bioimaging Applications of Carbon Nanodots: A Review

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

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