Mechanism of Jinzhen Oral Liquid against influenza-induced lung injury based on metabonomics and gut microbiome

Feng, Jian; Gao, Xia; Chen, Xialin; Tong, Xiaoyu; Qian, Mengyu; Gao, Huifang; Wang, Jiajia; Wang, Shan‐Li; Fei, Chenghao; Cao, Liang; Wang, Zhenzhong; Xiao, Wei

doi:10.1016/j.jep.2022.115977

Cited by 8 publications

(3 citation statements)

References 63 publications

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“…An increasing number of studies have found that the gut microbiota is not only essential for gut health but also involved in the occurrence and development of various diseases, such as metabolic, autoimmune and infectious diseases [28] , [29] , [30] . Evidence has shown that there were significant differences in the structure and function of the rumen microbiota between healthy and mastitis cows [31] .…”

Section: “Gastroenterogenic Mastitis”—in Addition To External Pathoge...mentioning

confidence: 99%

Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

Zhao

et al. 2024

Journal of Advanced Research

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Section: “Gastroenterogenic Mastitis”—in Addition To External Pathoge...mentioning

confidence: 99%

Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

Zhao

et al. 2024

Journal of Advanced Research

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“…The symbiotic microbiota, which consists of trillions of microorganisms, plays a crucial role in regulating various host physiological functions, such as digestion, nutrient metabolism, and immune system development [ 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 ]. Recently, mounting evidence has suggested that the gut microbiota modulates the host’s susceptibility to viral infections and contributes to various immune protective mechanisms against influenza virus infection [ 18 , 19 , 20 , 88 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ]. Neomycin-sensitive bacterial communities continuously provide signals for the transcription of Il1b and Il18 , contributing to pulmonary protective immune responses during influenza virus infection [ 18 , 139 ].…”

Section: The Role Of Commensal Microbiota In Influenza Virus Infectionmentioning

confidence: 99%

Roles and Mechanisms of NLRP3 in Influenza Viral Infection

Niu

Meng

2023

Viruses

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Pathogenic viral infection represents a major challenge to human health. Due to the vast mucosal surface of respiratory tract exposed to the environment, host defense against influenza viruses has perpetually been a considerable challenge. Inflammasomes serve as vital components of the host innate immune system and play a crucial role in responding to viral infections. To cope with influenza viral infection, the host employs inflammasomes and symbiotic microbiota to confer effective protection at the mucosal surface in the lungs. This review article aims to summarize the current findings on the function of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) in host response to influenza viral infection involving various mechanisms including the gut–lung crosstalk.

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“…16 More and more metabolomics has been studied in the regulation of metabolic disorders in various diseases. [24][25][26] It was of great significance to comprehensively understand the metabolome changes and the discovery of the potential biomarkers in mice infected with CRPA and the response for QGYD treatment. In this study, 11 potential metabolites that were abnormally expressed by CRPA infection and significantly reversed by QGYD were identified.…”

mentioning

confidence: 99%

Mechanism of Qiguiyin Decoction Treats Pulmonary Infection Caused by Pseudomonas aeruginosa Based on Gut Microbiota and Metabolomics

Cui¹,

Xu²,

Hu³

et al. 2023

IDR

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Background Qiguiyin decoction (QGYD) was a traditional Chinese medicine (TCM) used to treat Pseudomonas aeruginosa infection in China. This study investigated the therapeutic effect and the potential mechanism of QGYD on carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection. Materials and Methods Pulmonary infections were induced in mice by CRPA. The therapeutic effect of QGYD was evaluated by lung index and pulmonary pathology. The potential effects of QGYD on intestinal flora were detected by gut microbiome. The overall metabolism regulation of QGYD in blood was investigated by metabonomics. Next, the correlation between intestinal flora and metabolites was analyzed to illustrate the relationship between the regulatory effects of QGYD on metabolites and the beneficial effects of intestinal flora. Results QGYD has significant therapeutic effect on CRPA infection. QGYD profoundly inhibited the excessive accumulation of Deferribacteres and Mucispirillum at phylum and genus levels, respectively. Eleven potential metabolites that were abnormally expressed by CRPA infection and significantly reversed by QGYD were identified. Ten of the eleven metabolites significantly regulated by QGYD were related to Deferribacteres. Deferribacteres showed significant positive correlation with DL-lactic acid, phenylalanine and other metabolites and significant negative correlation with vitamin k1. At the genus level, Mucispirillum was closely related to metabolites significantly regulated by QGYD. Mucispirillum was positively correlated with metabolites such as Dl-lactate and negatively correlated with vitamin k1. Conclusion QGYD can improve CRPA infection and has the effect of regulating intestinal flora and metabolism. It was a promising drug against infection.

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Mechanism of Jinzhen Oral Liquid against influenza-induced lung injury based on metabonomics and gut microbiome

Cited by 8 publications

References 63 publications

Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

Roles and Mechanisms of NLRP3 in Influenza Viral Infection

Mechanism of Qiguiyin Decoction Treats Pulmonary Infection Caused by Pseudomonas aeruginosa Based on Gut Microbiota and Metabolomics

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