This paper investigates the effects of a 1.5-stage transonic axial compressor with applied aerodynamic mistuning via circumferential variation of the inlet guide vane stagger angle. The experiments were carried out at the Darmstadt Transonic Compressor at Technical University of Darmstadt. The test rig represents a modern front stage high-pressure compressor of a jet engine. Using extensive steady and unsteady instrumentation, the global compressor characteristics and performance as well as the transient behavior, focusing on aerodynamic and aeromechanic phenomena, are analyzed.In order to suppress non-synchronous blade vibration of the BLISK rotor, triggered by modal pattern of aerodynamic disturbances, asymmetric rotor inflow conditions are applied via circumferential pattern of varying pre-swirl, given by the inlet guide vane stagger angle. The experimental study provides proof of concept and snapshot measurements regarding global performance as well as steady and unsteady aerodynamic effects. Comparing different aerodynamic mistuning pattern, the influence on performance, circumferential flow variation, synchronous vibration as well as the behavior during stall inception varies. For all configurations, the circumferential variation of the rotors operating condition is evident within the radial and circumferential aerodynamics as well as unsteady flow at the rotor tip. These findings provide similarities to effects presented for asymmetric casing geometries and related mistuning capabilities.