Mechanism of Origin of Complete Hydatidiform Moles

Jacobs, Patricia A.; Willson, Carola M.; Sprenkle, Joyce A.; Rosenshein, Neil B.; Migeon, Barbara R.

doi:10.1097/00006254-198105000-00023

Cited by 5 publications

(6 citation statements)

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“…Complete moles (CM) are most often 46,XX with a genome that is entirely paternal in origin. Jacobs et al 3 . have demonstrated that CM most often arises from the fertilization of an ‘empty’ ovum by a haploid spermatozoon that subsequently duplicates without cytogenesis to restore the diploid number.…”

Section: Introductionmentioning

confidence: 99%

Over‐diagnosis of hydatidiform mole in early tubal ectopic pregnancy

et al. 2001

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Our results show that tubal ectopic hydatidiform mole is a rare entity and demonstrate that it is over-diagnosed. Polar trophoblastic proliferation and hydropic villi are features of early placentation and of hydropic abortion. Sheets of extravillous trophoblast may be particularly prominent in tubal ectopic gestation. In the absence of circumferential trophoblastic proliferation combined with hydropic change a diagnosis of gestational trophoblastic disease should be avoided.

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Section: Introductionmentioning

confidence: 99%

Over‐diagnosis of hydatidiform mole in early tubal ectopic pregnancy

et al. 2001

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“…Smith and King4 reported the isolation of C difficile from several extraintestinal sites, and more recently it has been implicated as the causative agent of pseudomembranous colitis. 5 The interesting features of this case are the unusual site of infection for this organism, the length of time over which the organism was isolated despite apparently appropriate treatment, and the development of penicillin resistance during treatment.…”

Section: Discussionmentioning

confidence: 93%

Twin pregnancy with complete hydatidiform mole (46,XX) and fetus (46,XY): genetic origin proved by analysis of chromosome polymorphisms.

Fisher¹,

Sheppard²,

Lawler³

1982

BMJ

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concentration was 12-5 mg/I. Treatment was changed to metronidazole 400 mg three times daily and cultures rapidly ceased to grow C difficile. The organism was not isolated over the succeeding 18 months and radiological changes suggested a resolving infection. The patient had no gastrointestinal symptoms at any time during the illness. DiscussionOsteomyelitis caused by anaerobic bacteria is rare, and we are not aware of any previous reports of C difficile causing this disease. C difficile was first isolated by Hall and O'Toole,3 who found it to be part of the normal gastrointestinal flora of infants. Smith and King4 reported the isolation of C difficile from several extraintestinal sites, and more recently it has been implicated as the causative agent of pseudomembranous colitis.5The interesting features of this case are the unusual site of infection for this organism, the length of time over which the organism was isolated despite apparently appropriate treatment, and the development of penicillin resistance during treatment.The source of the organism was probably the patient's own gastrointestinal tract, but the possibility of environmental infection cannot be excluded. Possibly the infection did not occur until after the initial drainage. The first abscess may have been sterile, as suggested by the first culture results, and merely a response to the foreign body present. It is unclear why the organism persisted for so long. On some occasions only very few organisms were present and thus enrichment media were required for isolation. The production of spores in vivo could explain the organism's persistence. The development of resistance to antibiotics during treatment is certainly not uncommon, and its occurrence in the present case added interest to an already interesting case. It is worth noting that transferable drug resistance in C difficile has recently been reported.

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“…15,16 CMs are seldom diagnosed before 6 weeks' GA, but improvements in ultrasonography have increased the numbers of moles evacuated early in pregnancy, increasing the chances of detecting embryonic development if this occurs in CM. Most large series of moles in which ploidy has been determined show a proportion of diploid moles diagnosed as PMs.…”

Section: Discussionmentioning

confidence: 99%

“…1) was observed in the presence of significant amounts of both molar and maternal tissue. Twenty cases were excluded from further analysis for one of the following reasons: no tissue available for flow cytometry (15); absence of maternal tissue as internal diploid control in the sample (4); and uninterpretable FC results (1). The genetic information derived from the study of short tandem repeat polymorphisms in seven cases with FRCs in molar villi is reported separately in the accompanying paper.…”

Section: Methodsmentioning

confidence: 99%