Mechanism of Palladium-Catalyzed Transfer Hydrogenolysis of Aryl Chlorides by Formate Salts

Combining Enabling Techniques in Organic Synthesis: Continuous Flow Processes with Heterogenized Catalysts

“…[27] Combination of microwave assistance and solid-phase-assisted catalysis: Alternatively, the combined microwave-assisted solid-phase technique was applied in the synthesis of several heterocycles [28] and natural product derivatives [29] [ Scheme 1. Catalysis under microwave irradiating conditions using heterogenized catalysts (supports: silica gel, glass, carbon and polymeric-materials; TBAB = tetra-n-butylammonium bromide).…”

Pd/C‐Catalyzed Transfer Reduction of Aryl Chlorides with Sodium Formate in Water

“…Therefore, the aid of a stable hydrogen donor represents a useful alternative method to the catalytic hydrodechlorination of aromatic chlorides by molecular hydrogen. These dechlorination systems involve the use of metal hydrides, [17] metal alkoxides, [6,18] hydrosilanes, [19,20] Grignard reagents, [21] alcohols, [22] and formic acid and its salts [23,24] as the hydrogen source. Formic acid and its salts are particularly versatile, and cheap reagents that have been used as a source of hydrogen in catalytic transfer hydrogenations and have frequently been applied in the reduction of a large variety of functional groups.…”

Synthesis of deuterated dihydrochalcones

“…Repetition of the reaction in methanol-d 1 0 and H5 0 ) was also observed. Reaction in methanol-d 1 using non-deuterated sodium formate and with omission of the formic acid 20 similarly gave 1a-d 4 with the same level of deuterium incorporation.…”