1989
DOI: 10.1099/0022-1317-70-12-3305
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Mechanism of Recovery from Acute Virus Infection. IX. Clearance of Lymphocytic Choriomeningitis (LCM) Virus from the Feet of Mice Undergoing LCM Virus-specific Delayed-type Hypersensitivity Reaction

Abstract: SUMMARYAs shown previously, after inoculation into the footpad of a mouse the lymphocytic choriomeningitis (LMC) virus multiplies locally. Beginning on day 6 or 7 after infection, the foot undergoes a delayed-type hypersensitivity (DTH) reaction which consists of two distinct phases that are mediated by CD8 + cells and CD4 + cells, respectively, and at about the same time the virus is eliminated. In general, for terminating infection of the mouse with LCM virus the CD8 + cytotoxic/suppressive T lymphocyte (CTL… Show more

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Cited by 12 publications
(3 citation statements)
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References 48 publications
(36 reference statements)
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“…LCMV. Subcutaneous inoculation of LCMV-WE into footpads of mice has been demonstrated to induce a virusspecific swelling reaction (6,7,(18)(19)(20). Wild-type mice and heterozygous mutant mice exhibited an initial major swelling that peaked on day 8, followed by a later minor swelling phase that started at around day 10, and then slowly declined in inflammation (Fig.…”
Section: Primary Local Swelling Reaction After Intrafootpad Infectionmentioning
confidence: 99%
See 1 more Smart Citation
“…LCMV. Subcutaneous inoculation of LCMV-WE into footpads of mice has been demonstrated to induce a virusspecific swelling reaction (6,7,(18)(19)(20). Wild-type mice and heterozygous mutant mice exhibited an initial major swelling that peaked on day 8, followed by a later minor swelling phase that started at around day 10, and then slowly declined in inflammation (Fig.…”
Section: Primary Local Swelling Reaction After Intrafootpad Infectionmentioning
confidence: 99%
“…2). The initial swelling has been shown to be mediated by CD8 § T cells, whereas the later swelling was mediated by CD4 + T cells (7,19,20). The CD4+ T cell-mediated swelling shown in mutant mice confirms that…”
Section: Primary Local Swelling Reaction After Intrafootpad Infectionmentioning
confidence: 99%
“…To study the effect of VLA-1 deficiency on the ability of effector T cells to accumulate at sites of viral infection, we used LCMV-induced T-cell-mediated meningitis as well as virus clearance in nonlymphoid organs as measures of the ability of CD8 þ T cells to migrate to sites of infection and exert their function locally [36,37]. In neither case did we observe a significant difference between VLA-1 -/-mice and wt controls, indicating that in most organs, Tc1 cells can extravasate and position themselves appropriately in the absence of VLA-1.…”
Section: Discussionmentioning
confidence: 99%