Mechanism of the Anticancer Effect of Lycopene (Tetraterpenoids)

Ono, Misaki; Takeshima, Mikako; Nakano, Susumu

doi:10.1016/bs.enz.2015.06.002

Cited by 63 publications

(27 citation statements)

References 119 publications

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“…Although the preclinical data strongly suggested lycopene has antitumour activity, several epidemiological studies indicate that its use for the prevention of cancers is controversial. However, because of its multiple tumour‐inhibitory activities, lycopene still remains a promising carotenoid for the prevention and treatment of human cancers (Bhuvaneswari and Nagini, ; Ono et al ., ). Furthermore, a significant inverse association has been observed between HPV persistence and plasma cis ‐lycopene concentrations; lycopene induced a ~56% reduction in viral load (Sedjo et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Carotenoids: biochemistry, pharmacology and treatment

Milani

Basirnejad

Shahbazi

et al. 2016

British J Pharmacology

590

376

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*Joint first authors.Carotenoids and retinoids have several similar biological activities such as antioxidant properties, the inhibition of malignant tumour growth and the induction of apoptosis. Supplementation with carotenoids can affect cell growth and modulate gene expression and immune responses. Epidemiological studies have shown a correlation between a high carotenoid intake in the diet with a reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular and eye diseases. Cancer chemoprevention by dietary carotenoids involves several mechanisms, including effects on gap junctional intercellular communication, growth factor signalling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, the Wnt/β-catenin pathway and inflammatory cytokines. Moreover, carotenoids can stimulate the proliferation of B-and T-lymphocytes, the activity of macrophages and cytotoxic T-cells, effector T-cell function and the production of cytokines. Recently, the beneficial effects of carotenoid-rich vegetables and fruits in health and in decreasing the risk of certain diseases has been attributed to the major carotenoids, β-carotene, lycopene, lutein, zeaxanthin, crocin (/crocetin) and curcumin, due to their antioxidant effects. It is thought that carotenoids act in a time-and dose-dependent manner. In this review, we briefly describe the biological and immunological activities of the main carotenoids used for the treatment of various diseases and their possible mechanisms of action.

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Section: Introductionmentioning

confidence: 97%

Carotenoids: biochemistry, pharmacology and treatment

Milani

Basirnejad

Shahbazi

et al. 2016

British J Pharmacology

590

376

View full text Add to dashboard Cite

show abstract

“…However, recent studies have revealed the potential roles of lycopene, such as removal of free radicals, alleviation of bio-oxidative stress, modulation of body immune functions, and prevention of cardiovascular disease (Trejo-Solís et al, 2013;Cefali et al, 2015;Ilahy et al, 2016). In addition, lycopene can exert anti-tumor effects via regulation of cell growth factor signaling pathways, initiation of cell cycle arrest, and induction of cell apoptosis (Ono et al, 2015). Being a natural component in daily diet, lycopene has several advantages such as fewer adverse effects and easy extraction method, which attract extensive research interests in its anti-tumor effects.…”

Section: Introductionmentioning

confidence: 99%

In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells

Peng¹,

Li²,

Zhou³

et al. 2017

Genet. Mol. Res.

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Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we aimed to illustrate the effect of lycopene on tumor cell proliferation and modulation of cancer progression as well as its possible underlying mechanisms in human breast carcinoma cell line MCF-7 in vitro. MCF-7 cells were treated with different lycopene concentrations for 24, 48, and 72 h. Light field microscopy was used to observe cell morphology. MTT assay was used to determine the effect of lycopene on MCF-7 proliferation. Flow cytometry was employed to evaluate cell apoptosis. Real-time quantitative polymerase chain reaction was performed to detect the expression of p53 and Bax. Under microscopic examination, the untreated MCF-7 cells appeared to have a diamond or polygonal shape. Lycopene treatment resulted in cell shrinkage and breakage, whose severity increased in a dose and duration dependent manner. In addition, reduced cell proliferation and increased apoptosis (P < 0.05) were observed using MTT assay and flow cytometry, respectively. Moreover, lycopene could also upregulate the expression of p53 and Bax mRNAs in MCF-7 cells. In conclusion, lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax.

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“…Lycopene may also reduce oxidative stress by down-regulating expression of ROS generating proteins such as ERO-1 like protein-α and CLIC-1 [109]. Furthermore, lycopene has also been shown to inhibit cell proliferation, induce apoptosis, and in prostate cancer models, has shown to attenuate the metastatic capacity of cancer cells [109, 110]. …”

Section: Lycopenementioning

confidence: 99%

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

2016

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Cancer chemoprevention involves the use of different natural or biologic agents to inhibit or reverse tumor growth. Epidemiological and pre-clinical data suggest that various natural phytochemicals and dietary compounds possess chemopreventive properties, and in-vitro and animal studies support that these compounds may modulate signaling pathways involved in cell proliferation and apoptosis in transformed cells, enhance the host immune system and sensitize malignant cells to cytotoxic agents. Despite promising results from experimental studies, only a limited number of these compounds have been tested in clinical trials and have shown variable results. In this review, we summarize the data regarding select phytochemicals including curcumin, resveratrol, lycopene, folates and tea polyphenols with emphasis on the clinical evidence supporting the efficacy of these compounds in high-risk populations.

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Mechanism of the Anticancer Effect of Lycopene (Tetraterpenoids)

Cited by 63 publications

References 119 publications

Carotenoids: biochemistry, pharmacology and treatment

Carotenoids: biochemistry, pharmacology and treatment

In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

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