Mechanisms and clinical uses of capsaicin

Sharma, Surinder K.; Vij, Amarjit Singh; Sharma, Mohit

doi:10.1016/j.ejphar.2013.10.053

Cited by 285 publications

(243 citation statements)

References 113 publications

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“…It has been used as an analgesic against arthritis pain and inflammation (Srinivasan 2013). A beneficial role of capsaicin has been reported in obesity, cardiovascular and gastrointestinal conditions, various cancers, neurogenic bladder, and dermatologic conditions (Sharma et al 2013).…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the capsaicinoid and phenolic contents and in vitro antioxidant activities of the peppers of the genus Capsicum: an application of chemometrics

et al. 2015

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This paper presents a comparison of the contents of capsaicin, dihydrocapsaicin and total phenolics as well as of the antioxidant activities of six types of peppers of the genus Capsicum. The varieties were analyzed in terms of their in vitro antioxidant activity using ferric reducing antioxidant powder (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis 3-ethylbenzothiazoline 6-sulfonate (ABTS •+ ) assays. The contents of phenolics and capsainoids as well as the antioxidant activities were higher in seeds than in pulps. The correlations (ρ<0.01) between the phenolic composition and the capsaicinoids levels were high (r=0.98). Similarly high were also the correlations between the antioxidant activities and the contents of total phenolics and capsaicinoids. Data were analyzed using principal component analysis (PCA), hierarchical cluster analysis (HCA) and multiple linear regression (MLR). PCA explained 97.77 % of the total variance of the data, and their separation into three groups in a scatter plot was divised. Using HCA, three clusters were suggested. Cluster one, formed by pulps (bell pepper, orange habanero, cayenne, dedo de moça and red habanero), showed the lowest levels of the compounds quantified. Most seed samples were grouped in cluster two (bell pepper, cayenne, dedo de moça and malagueta) together with malagueta pulp. Cluster three was formed by orange and red habanero seeds, which showed the highest levels of all compounds analyzed. The MRL revealed that the values of capsaicinoids and total phenols are more adequate to predict the antioxidant activity measured by the FRAP assay.

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Section: Introductionmentioning

confidence: 99%

A comparative study of the capsaicinoid and phenolic contents and in vitro antioxidant activities of the peppers of the genus Capsicum: an application of chemometrics

et al. 2015

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“…Capsinoid are unstable and easily degraded in the aqueous phase. Therefore, capsinoid has advantage over capsaicinoid in biomedical uses (Sharma et al 2013) .…”

Section: Introductionmentioning

confidence: 99%

Substitution of a Dysfunctional pAMT Allele Results in Low-Pungency but High Levels of Capsinoid in Capsicum chinense ‘Habanero’

Jang

Han

et al. 2015

Plant Breed. Biotech.

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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Capsinoids are the class of secondary metabolites identified in non-pungent peppers exhibiting the same bioactive properties as capsaicinoid. Previously, it has been demonstrated that capsinoid production is controlled by the capsaicin synthase (CS) gene and the putative-aminotransferase (pAMT) gene. In this study, we report that C. chinense 'SNU11-001' containing high levels of capsinoid has an early stop codon in pAMT resulted from 403 bp and 8 bp insertions deletion in the third and sixth exons. In order to know whether CS expression is correlated with the level of capsinoid, CS and pAMT expressions were determined using SNU11-001 and four Capsicum accessions with different pungency level. RT-PCR analysis showed higher transcription levels of CS in pungent accessions but no clear differences in pAMT expression. To investigate the effect of the substitution of the pAMT allele of C. chinense 'Habanero' with the dysfunctional pAMT allele of SNU11-001, an F2 population was constructed by a cross between aforementioned parental lines. Molecular markers were developed to distinguish CS and pAMT genotypes of SNU11-001 and Habanero and F2 plants were genotyped. All F2 plants having the pAMT genotype of SNU11-001 contained high levels of capsinoid while very low levels of capsaicinoid. There was no significant difference in levels of capsinoid among the F2 plants regardless of CS genotypes. This may be due to strong CS expression of both parental lines. In conclusion, our results show that it is possible to develop a new Habanero cultivar with high capsinoid content by introducing a dysfunctional pAMT allele.

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“…Most of our appendicitis patients eat grains only one time daily, Cummings and colleagues 14 found bran to cause the greatest increase in fecal weight of the dietary fibers they studied (23).…”

Section: Discussion:-mentioning

confidence: 88%

Relationship Between Appendicitis and Lifestyle; Dietary and Hygiene in Saudi Arabia.

Alzahrani¹,

Sehli²,

Alsharif³

et al. 2017

IJAR

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Mechanisms and clinical uses of capsaicin

Cited by 285 publications

References 113 publications

A comparative study of the capsaicinoid and phenolic contents and in vitro antioxidant activities of the peppers of the genus Capsicum: an application of chemometrics

A comparative study of the capsaicinoid and phenolic contents and in vitro antioxidant activities of the peppers of the genus Capsicum: an application of chemometrics

Substitution of a Dysfunctional pAMT Allele Results in Low-Pungency but High Levels of Capsinoid in Capsicum chinense ‘Habanero’

Relationship Between Appendicitis and Lifestyle; Dietary and Hygiene in Saudi Arabia.

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