Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo

MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers

“…Both at day 9 and day 12, we observed higher expression levels of Ifng and granzyme B (Gzmb) in WT CD3 + CD8 + T cells compared with miR-155 TCKO counterparts, on average ( Figure 2C). Both IFN-γ and Gzmb are critical mediators of T cell cytotoxicity against tumors and pathogens (21). An elevated expression of other activation marker genes such as Pdcd1 (encoding PD-1) and Tnfrsf9 (encoding 4-1BB) were observed in WT T cells, particularly by day 12 of tumor progression.…”

The Broad Spectrum of Human Natural Killer Cell Diversity

“…However, the ways in which these two cell types develop in the body, detect infected or malignantly transformed cells, and become activated are distinct. T cells develop in the thymus and become activated when their somatically rearranged T cell receptors (TCRs) encounter foreign antigen in the context of self major histocompatibility complex (MHC) molecules and costimulatory ligands expressed on antigen presenting cells (Halle et al, 2017). In contrast, NK cells primarily develop outside of the thymus in various other tissues, and they do not express a rearranged TCR (Ritz et al, 1985; Yu et al, 2013).…”

The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis

“…CTLs express FAS ligands (FASL) on their surface ( Fig. 1) (Halle et al, 2017). The trimerized ligands bind the DRs expressed on the cell surface, leading to DR clustering and binding of the adaptor protein FADD, which consequently results in the recruitment of initiator caspase-8/-10.…”